Synthesis and release of prostaglandins D2 and E2 by rat uterine tissue throughout the sex cycle. Effects of 17-β-estradiol and progesterone

Chaud, M.; Faletti, A.; Estrada, Matias; Gimeno, A.L.; Gimeno, M.F.

doi:10.1016/0952-3278(94)90177-5

Cited by 12 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, rat uterine PGD 2 and PGE 2 production varies similarly during the sex cycle and 17‐β‐estradiol negatively regulates their synthesis. In addition, progesterone depressed only PGD 2 synthesis without affecting PGE 2 production 52 . This finding does not support the elevation of PGD 2 in the endometrium during the mid‐luteal phase in humans and sheep.…”

Section: Introductionmentioning

confidence: 58%

Prostaglandin D₂ and Reproduction

Saito

Tsuda

Michimata

2002

American J Rep Immunol

View full text Add to dashboard Cite

This review highlights recent studies investigating the role of prostaglandin (PG)D2 in reproduction. PGD2 induces sleep, allergic responses, inhibition of platelet aggregation, and relaxation of vascular and non-vascular smooth muscle, and has some roles in reproduction. Two types of PGD2 synthase are known. Lipocalin-type PGD synthase is present in cerebrospinal fluid, seminal plasma and may play an important role in male reproduction. Another PGD synthase, hematopoietic PGD synthase is present in the spleen, fallopian tube, endometrial gland cells, extravillous trophoblasts and villous trophoblasts, and perhaps plays an important role in female reproduction. Recent studies demonstrate that PGD2 is probably involved in multiple aspects of inflammation through its dual receptor systems, DP and CRTH2. CRTH2 but not DP is a chemo-attractant receptor for PGD2. Interestingly, CRTH2 is a most reliable marker for the detection of human T helper type 2 (Th2) and T cytotoxic type 2 (Tc2) cells, and the percentages of CRTH expressing CD4+-T cells and CD8+-T cells were significantly higher in the decidua especially at the implantation site, suggesting that Th2 and Tc2 cells recruit into the materno-fetal interface, in a PGD2-mediated manner. PGD2 has a very unique effect to inhibit antigen presentation by inhibition of dendritic cell (DC) migration through DP but not CRTH2. PGD2 might appear to contribute to the maintenance of pregnancy by controlling the Th1/Th2 balance and antigen presentation by DCs through its dual receptor systems, CRTH2 and DP.

show abstract

Section: Introductionmentioning

confidence: 58%

Prostaglandin D₂ and Reproduction

Saito

Tsuda

Michimata

2002

American J Rep Immunol

View full text Add to dashboard Cite

show abstract

“…We are unaware of any experiments addressing this possibility. Nonetheless, in a variety of peripheral tissues, PGE synthesis and release was greater at proestrus than at diestrus (11,37). Furthermore, oxytocin-stimulated PGE 2 release in cultured bovine endometrium is enhanced by estrogen (1).…”

Section: Discussionmentioning

confidence: 99%

Interleukin-1β fever in rats: gender difference and estrous cycle influence

Mouihate

Chen

Pittman

1998

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

Evidence exists to support the concept of sex difference in immune system activation by pyrogenic cytokines. In this study, fever development was monitored to analyze the effect of peripheral administration of interleukin (IL)-1β (1 μg/kg) in adult male and cycling or ovariectomized female rats with or without ovarian hormonal replacement. In male and randomly cycling female rats, a similar increase in body temperature occurred after intraperitoneal IL-1β injection. Two representative stages of estrus with higher and lower levels of ovarian hormones (proestrus and diestrus, respectively) were chosen for study of the febrile response induced by IL-1β. The fever induced by IL-1β was found to be significantly higher and more prolonged in females at proestrus than at diestrus. The differential fever response seems to be mainly linked to the ovarian hormonal levels because bilaterally ovariectomized females, supplemented with sequential injections of estradiol 17β and progesterone, showed a significantly higher IL-1β fever than did ovariectomized rats receiving estradiol 17β only. These results indicate that gonadal hormones can influence fever development and raise the possibility of interaction between sex hormones and thermogenesis in females during the estrous cycle.

show abstract

“…The biological mechanism responsible for the association between alcohol use and preterm birth complications may be explained in terms of an enhanced prostaglandin level among drinkers, because a rise in prostaglandin level can cause preterm birth [209]. Progesterone hormone has been shown to suppress prostaglandin production [210][211][212], which is an important regulator of prostaglandin synthesis during parturition. Heavy alcohol exposure decreases the progesterone synthesis and level [213,214], hence resulting in failure to control the prostaglandin level and leading eventually to the onset of the physiological events associated with parturition [209,215].…”

Section: Preterm Birth Complicationsmentioning

confidence: 99%

The relation between different dimensions of alcohol consumption and burden of disease: an overview

Rehm

Baliunas

Borges³

et al. 2010

Addiction

928

815

View full text Add to dashboard Cite

AIMS As part of a larger study to estimate the global burden of disease and injury attributable to alcohol: To evaluate the evidence for a causal impact of average volume of alcohol consumption and pattern of drinking on diseases and injuries;To quantify relationships identified as causal based on published meta-analyses;To separate the impact on mortality vs. morbidity where possible; andTo assess the impact of the quality of alcohol on burden of disease. METHODS Systematic literature reviews were used to identify alcohol-related diseases, birth complications and injuries using standard epidemiologic criteria to determine causality. The extent of the risk relations was taken from meta-analyses. RESULTS Evidence of a causal impact of average volume of alcohol consumption was found for the following major diseases: tuberculosis, mouth, nasopharynx, other pharynx and oropharynx cancer, oesophageal cancer, colon and rectum cancer, liver cancer, female breast cancer, diabetes mellitus, alcohol use disorders, unipolar depressive disorders, epilepsy, hypertensive heart disease, ischaemic heart disease (IHD), ischaemic and haemorrhagic stroke, conduction disorders and other dysrhythmias, lower respiratory infections (pneumonia), cirrhosis of the liver, preterm birth complications, foetal alcohol syndrome. Dose-response relationships could be quantified for all disease categories except for depressive disorders, with the relative risk increasing with increased level of alcohol consumption for most diseases. Both average volume and drinking pattern were causally linked to IHD, foetal alcohol syndrome, and unintentional and intentional injuries. For IHD, ischaemic stroke and diabetes mellitus beneficial effects were observed for patterns of light to moderate drinking without heavy drinking occasions (as defined by 60+ grams pure alcohol per day). For several disease and injury categories, the effects were stronger on mortality compared to morbidity. There was insufficient evidence to establish whether quality of alcohol had a major impact on disease burden. CONCLUSIONS Overall, these findings indicate that alcohol causally impacts many disease outcomes, both chronic and acute, and injuries. In addition, a pattern of heavy episodic drinking increases risk for some disease and all injury outcomes. Future studies need to address a number of methodological issues, especially the differential role of average volume versus drinking pattern, in order to obtain more accurate risk estimates and to better understand the nature of alcohol-disease relationships.

show abstract

Synthesis and release of prostaglandins D2 and E2 by rat uterine tissue throughout the sex cycle. Effects of 17-β-estradiol and progesterone

Cited by 12 publications

References 17 publications

Prostaglandin D₂ and Reproduction

Prostaglandin D₂ and Reproduction

Interleukin-1β fever in rats: gender difference and estrous cycle influence

The relation between different dimensions of alcohol consumption and burden of disease: an overview

Contact Info

Product

Resources

About

Synthesis and release of prostaglandins D2 and E2 by rat uterine tissue throughout the sex cycle. Effects of 17-β-estradiol and progesterone

Cited by 12 publications

References 17 publications

Prostaglandin D2 and Reproduction

Prostaglandin D2 and Reproduction

Interleukin-1β fever in rats: gender difference and estrous cycle influence

The relation between different dimensions of alcohol consumption and burden of disease: an overview

Contact Info

Product

Resources

About

Prostaglandin D₂ and Reproduction

Prostaglandin D₂ and Reproduction