Synthesis and reduction-responsive disassembly of PLA-based mono-cleavable micelles

Cunningham, Alexander J.; Ko, Na Re; Oh, Jung Kwon

doi:10.1016/j.colsurfb.2014.08.002

Cited by 28 publications

(15 citation statements)

References 73 publications

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“…The polymer, however, has to be synthetically/chemically modified pre-or post-fabrication of the delivery system to incorporate the targeting or stimuli-responsive moiety Hence, PLA based blends used for active delivery systems usually involve the use of modified PLA or its copolymer like PLGA [123][124][125][126][127][128]. In addition, multifunctionality can play an important role in receptor-mediated delivery to attain maximum interaction and avidity of delivery vehicles with the available receptors.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Poly(lactic acid) blends in biomedical applications

Saini

Arora

Kumar

2016

Advanced Drug Delivery Reviews

416

258

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Section: Accepted Manuscriptmentioning

confidence: 99%

Poly(lactic acid) blends in biomedical applications

Saini

Arora

Kumar

2016

Advanced Drug Delivery Reviews

416

258

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“…Cunningham et al designed a reduction-responsive triblock copolymer comprising biocompatible polylactide (PLA) and PEG blocks [34]. The copolymer self-assembles to form colloidally-stable mono-cleavable micelles having single disulfides in hydrophobic PLA cores surrounded with PEG coronas in aqueous solution.…”

Section: Introductionmentioning

confidence: 99%

Synthesis strategies for disulfide bond-containing polymer-based drug delivery system for reduction-responsive controlled release

Liu

2015

Front. Mater. Sci.

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Tumor micro-environment responsive drug delivery systems (DDSs) have been developed as a potential approach to reduce the side effects of cancer chemotherapy. Glutathione (GSH) has been supposed to the most significant signal of the difference between the normal tissue and the tumor cells, besides the media pH and temperature. In recent years, the reduction-responsive DDSs have attracted more and more attention for delivery of anti-cancer drugs, based on such physiological signal. Among them, disulfide bond-containing polymers have been designed as the main tool for the purpose. The recent progress in the synthesis strategies for the disulfide bondcontaining polymer-based DDS is focused in the present review.

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“…Particularly, reduction‐sensitive polymer nanomaterials containing disulfide groups have been designed to promote the efficiency of drug delivery and release, according to the higher concentration of the reducing agent glutathione in cell interior (2–10 mM) than the extracellular environments (2–10 μM) . For instance, Oh and coworkers have conducted a number of works about reduction‐sensitive copolymers used as drug carriers to accelerate the drug release . Zhong and coworkers have reported a series of studies about reduction‐sensitive nanomaterials for the controlled cytoplasmic delivery of a variety of biomolecules including drugs, DNA, proteins, siRNA, and so forth .…”

Section: Introductionmentioning

confidence: 99%

“…[11][12][13][14][15][16][17][18] For instance, Oh and coworkers have conducted a number of works about reduction-sensitive copolymers used as drug carriers to accelerate the drug release. [19][20][21] Zhong and coworkers have reported a series of studies about reduction-sensitive nanomaterials for the controlled cytoplasmic delivery of a variety of biomolecules including drugs, DNA, proteins, siRNA, and so forth. [22][23][24][25][26][27] Their results indicate that reduction-sensitive biodegradable polymer assemblies are highly promising biomaterials which have excellent stability in the circulation and in extracellular fluids but rapidly degrade under the reducing environment presenting in tumor tissues and intracellular apparatus.…”

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confidence: 99%

Effect of pH and content of reduction‐sensitive copolymer on the guest exchange kinetics of micelles

Fan

et al. 2018

J Polym Sci B Polym Phys

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The micelles formed by reduction‐sensitive amphiphilic copolymer have emerged as promising drug nanocarriers due to the controlled drug release and effective anticancer activity triggered by the reducing stimulation. However, the effect of pH on the stability and guest exchange of the micelles formed by reduction‐sensitive copolymer have not been systemically investigated. Herein, the micelles formed by a reduction‐sensitive copolymer poly(ε‐caprolactone)‐b‐poly[oligo(ethylene glycol) methyl ether methacrylate] (PCL–SS–POEGA) with a single disulfide group at different pH values loaded with dyes 3,3′‐dioctadecyloxacarbocyanine perchlorate/1,1′‐dioctadecyl‐3,3,3′,3′‐tetramethylindocarbocyanine perchlorate (DiO/DiI) were prepared through the precipitation‐dialysis method. In addition, mixed micelles formed by different contents of reduction‐sensitive and reduction‐insensitive copolymers encapsulated with DiO/DiI at pH 7.5 were also prepared by the similar approach. The effects of pH and the content of reduction‐sensitive copolymer on guest exchange of these micelles were studied by the fluorescence resonance energy transfer method. Results show that the pH value in the environment has great influence on the guest exchange rate of reduction‐sensitive micelles in the presence of 10 mM dithiothreitol (DTT) and slight effect on that in the absence of DTT. Under a reducing environment, the guest exchange rate of the micelles containing various contents of disulfide‐linked copolymer increases with the increasing content of PCL–SS–POEGA. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2018, 56, 1636–1644

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Synthesis and reduction-responsive disassembly of PLA-based mono-cleavable micelles

Cited by 28 publications

References 73 publications

Poly(lactic acid) blends in biomedical applications

Poly(lactic acid) blends in biomedical applications

Synthesis strategies for disulfide bond-containing polymer-based drug delivery system for reduction-responsive controlled release

Effect of pH and content of reduction‐sensitive copolymer on the guest exchange kinetics of micelles

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