Synthesis and reactivity ofN-substituted aminoamides, antiarrhythmic and local anaesthetic activity

Synthesis and antimicrobial activity of new carbamoyl-containing oxa(thia)zolidines and 3-dialkylaminobutanamides

“…4-Hydroxybutanamides can be considered as prodrugs subjected to lactonization immediately in the organism, which leads to certain biological effects [5,6]. However, there is still no commonly accepted opinion as to whether 7-hydroxybutyric acid occurs in the organism in an open form or as a cyclic y-butyrolactone [5,7,8].…”

“…However, there is still no commonly accepted opinion as to whether 7-hydroxybutyric acid occurs in the organism in an open form or as a cyclic y-butyrolactone [5,7,8].…”