Synthesis and Reactions of Acenaphthenequinones. Part 2. The Reactions of Acenaphthenequinones

Abstract

The reactions of acenaphthenequinone and its derivatives with different nucleophiles, organic and inorganic reagents are reviewed. This survey also covers their oxidation and reduction reactions, in addition to many known reactions such as Friedel Crafts, Diels-Alder, bromination and thiolation.

Novel 9-(alkylthio)-Acenaphtho[1,2-e]-1,2,4-triazine derivatives: synthesis, cytotoxic activity and molecular docking studies on B-cell lymphoma 2 (Bcl-2)

“…Various reactions of acenaphthaquinone with nucleophiles, organic and inorganic reagents have been reviewed elsewhere [ 20 , 21 ]. In the framework of our program to develop the chemistry of potentially bioactive heterocyclic compounds [ 22 ] and in connection with our ongoing interests in this field [ 23 - 25 ], we represent here a facile procedure for the synthesis of 9-(alkylthio)-acenaphtho[1,2-e]-1,2,4-triazines via two step condensation of thiosemicarbazide and acenaphtylene-9,10-quinone to form acenaphtho[1,2-e]-1,2,4-triazine-9(8H)-thiones and subsequent reaction with benzyl chloride derivatives.…”