Synthesis and reactions of 5-aryl-2-thiophenecarbaldehydes

Design and Synthesis of Novel 5-(4-chlorophenyl)furan Derivatives with Inhibitory Activity on Tubulin Polymerization

“…General procedure for synthesis of compounds 1a-b Compounds 1a, b were prepared adopting previously reported methods [16,17].…”

Catalytic Deprotonative α-Formylation of Heteroarenes by an Amide Base Generated in Situ from Tetramethylammonium Fluoride and Tris(trimethylsilyl)amine

“…Mp: 83–84 °C (AcOEt/hexane) (lit. 74–76 °C; 88–89 °C). 1 H NMR (400 MHz, CDCl 3 /TMS): δ 7.33–7.48 (m, 3H), 7.55–7.67 (m, 2H), 7.73 (d, 1H, J = 3.9 Hz), 9.88 (s, 1H).…”

Transition Metal‐Mediated Direct CH Arylation of Heteroarenes Involving Aryl Radicals

“…ditions to the arylation of benzofuran, indole and pyridine led to lower yields. Obushak and co-workers observed that 2-thio-A C H T U N G T R E N N U N G phenecarbaldehydes [54] and 2-acetylthiophene [55] displayed a lower reactivity (20-55%, Scheme 18) toward the radical arylation with arenediazonium salts, under copper-catalyzed reaction conditions, than did their corresponding furan congeners (compare Scheme 15 with Scheme 18). It should be noted that a similar trend was previously briefly communicated during the preparation of compounds having potential fluorescent properties.…”