Synthesis and radical polymerization of styrene derivative bearing kojic acid moieties

Tomita, Ikuyoshi; Mitsuhashi, Kenji; Endō, Takeshi

doi:10.1002/(sici)1099-0518(19960130)34:2<271::aid-pola13>3.0.co;2-n

Cited by 11 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are also other reports on the synthesis of KA dimers similar to 54 from aldol reaction of KA with various aldehydes. 57,58 Synthesis and radical polymerization of styrene derivative containing KA moieties 56 was reported by Tomita et al 59 p -Formyl styrene was reacted with 2 equiv. KA in the presence of Na 2 CO 3 in MeOH under N 2 atmosphere at reflux for 4 h and then protected with acetic anhydride in pyridine at room temperature to afford styrene derivative 56 in 90% yield.…”

Section: Scheme 17mentioning

confidence: 98%

Kojic acid in organic synthesis

Zirak¹,

Eftekhari‐Sis²

2015

Turk J Chem

View full text Add to dashboard Cite

The reactions of kojic acid in organic synthesis are reviewed. The aim of this review is to cover the literature up to the end of 2014, showing the distribution of publications involving kojic acid chemistry in the synthesis of various pyrone containing compounds, pyridine and pyridone heterocycles, and also other organic compounds. First, introductory text about the preparation, biological, and industrial applications, and the chemical properties of kojic acid is given.Then its uses in organic synthesis are presented considering the reaction type.

show abstract

Section: Scheme 17mentioning

confidence: 98%

Kojic acid in organic synthesis

Zirak¹,

Eftekhari‐Sis²

2015

Turk J Chem

View full text Add to dashboard Cite

show abstract

“…Furthermore, kojic acid is also used as a building block for biodegradable plastics [3,4]. Plastics have phenolic hydroxyl groups that are derived from kojic acid.…”

Section: Introductionmentioning

confidence: 99%

“…Kojic acid (5-Hydroxy-2-(hydroxymethyl)-4-pyrone) is widely used in the food industry, pharmaceutical industry, and in cosmetics [ 1 , 2 ]. Furthermore, kojic acid is also used as a building block for biodegradable plastics [ 3 , 4 ]. Plastics have phenolic hydroxyl groups that are derived from kojic acid.…”

Section: Introductionmentioning

confidence: 99%

Aspergillus oryzae-based cell factory for direct kojic acid production from cellulose

et al. 2014

View full text Add to dashboard Cite

BackgroundKojic acid (5-Hydroxy-2-(hydroxymethyl)-4-pyrone) is one of the major secondary metabolites in Aspergillus oryzae. It is widely used in food, pharmaceuticals, and cosmetics. The production cost, however, is too high for its use in many applications. Thus, an efficient and cost-effective kojic acid production process would be valuable. However, little is known about the complete set of genes for kojic acid production. Currently, kojic acid is produced from glucose. The efficient production of kojic acid using cellulose as an inexpensive substrate would help establish cost-effective kojic acid production.ResultsA kojic acid transcription factor gene over-expressing the A. oryzae strain was constructed. Three genes related to kojic acid production in this strain were transcribed in higher amounts than those found in the wild-type strain. This strain produced 26.4 g/L kojic acid from 80 g/L glucose. Furthermore, this strain was transformed with plasmid harboring 3 cellulase genes. The resultant A. oryzae strain successfully produced 0.18 g/L of kojic acid in 6 days of fermentation from the phosphoric acid swollen cellulose.ConclusionsKojic acid was produced directly from cellulose material using genetically engineered A. oryzae. Because A. oryzae has efficient protein secretion ability and secondary metabolite productivity, an A. oryzae-based cell factory could be a platform for the production of various kinds of bio-based chemicals.

show abstract

“…Kojic acid is also used as a raw material for the synthesis of biodegradable plastics [17]. It is produced on an industrial scale using Aspergillus spp and Penicillium spp.…”

Section: Introductionmentioning

confidence: 99%

Repeated-batch production of kojic acid in a cell-retention fermenter using Aspergillus oryzae M3B9

Wan

Chen

Giridhar

et al. 2005

J IND MICROBIOL BIOTECHNOL

View full text Add to dashboard Cite

A cell-retention fermenter was used for the pilot-scale production of kojic acid using an improved strain of Aspergillus oryzae in repeated-batch fermentations. Among the various carbon and nitrogen sources used, sucrose and yeast extract promoted pellet morphology of fungi and higher kojic acid production. Repeated-batch culture using a medium replacement ratio of 75% gave a productivity of 5.3 gL(-1)day(-1) after 11.5 days of cultivation. While batch culture in shake-flasks resulted in a productivity of 5.1 gL(-1)day(-1), a productivity of 5 gL(-1)day(-1) was obtained in a pilot-scale fermenter. By converting the batch culture into repeated batches, the non-productive downtime of cleaning, filling and sterilizing the fermenter between each batch were eliminated, thereby increasing the kojic acid productivity.

show abstract

Synthesis and radical polymerization of styrene derivative bearing kojic acid moieties

Cited by 11 publications

References 0 publications

Kojic acid in organic synthesis

Kojic acid in organic synthesis

Aspergillus oryzae-based cell factory for direct kojic acid production from cellulose

Repeated-batch production of kojic acid in a cell-retention fermenter using Aspergillus oryzae M3B9

Contact Info

Product

Resources

About