Synthesis and property of chitosan graft copolymer by RAFT polymerization with tosylic acid–chitosan complex

Jiang, Jing; Pan, Xiaodi; Cao, Jianxin; Jiang, Jianlin; Hua, Daoben; Zhu, Xiulin

doi:10.1016/j.ijbiomac.2012.01.033

Cited by 22 publications

(7 citation statements)

References 34 publications

(36 reference statements)

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“…living free radical nitroxide-mediated polymerization, atom transfer radical polymerization and reversible addition-fragmentation chain transfer (RAFT) polymerization [30]. Atom transfer radical polymerization (ATRP) refers to a system where equilibrium between dormant species and radicals is established [31].…”

Section: Chitosan Co-polymersmentioning

confidence: 99%

Chitosan as an Advanced Healthcare Material

Jardine

Sayed

2014

Advanced Biomaterials and Biodevices

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Chitin and chitosan are renewable biopolymers with inherently favourable properties allowing diverse chemical modifi cation that generates novel materials ideal for biomedical applications. Chitin itself has very poor aqueous solubility and hence found limited utility. For this reason the use of chitosan, in particular, modifi ed chitosan, has increased exponentially in biomedical applications in recent years. Th e review of chitosan as a health care material includes wound healing or tissue regeneration, drug delivery and antimicrobial studies. Specialist applications are vast and due to the shortened publication process, biomedical applications of chitosan may warrant more frequent reviews.In this review, highlights of recent research on the synthesis and analysis of chitin and chitosan based nanomaterials and nanofi bres will be covered. A detailed review of the synthetic transformation of chitosan that further added value by enabling diverse application has been discussed. Th e value of copolymerization and graft ing of biodegradable synthetic polymers with chitosan in order to improve stability and control of the functional biomaterial has been a major driver in the biotechnological innovation.

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Section: Chitosan Co-polymersmentioning

confidence: 99%

Chitosan as an Advanced Healthcare Material

Jardine

Sayed

2014

Advanced Biomaterials and Biodevices

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“…Chitosan graft copolymers were synthesized by a couple of groups by using various types of CTA agents. [7][8][9][10][11][12] The strategy of in-situ polymerizing the monomers (e.g. PNIPAAm, acrylic acid, tosylic acid, etc.)…”

Section: Introductionmentioning

confidence: 99%

On the Development of Chitosan-Graft-Poly(n-Isopropylacrylamide) by Raft Polymerization Technique

Cheaburu-Yılmaz¹

2020

Cellulose Chem. Technol.

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The present paper aimed the synthesis of a functional biopolymer based on chitosan-graft-poly(N-isopropylacrylamide) (CS-g-PNIPAAm) using the "grafting from" technique via reversible addition-fragmentation chain transfer (RAFT) polymerization. Two different chain transfer agents, both compatible with the acrylic monomer were used. All intermediary products obtained from each step of chemical synthesis were quantified by ATR-FT-IR, 1 H-NMR and elemental analysis. Thermal properties confirmed that, with the chemical modification, chitosan structures became more complex and more thermally stable. The grafting efficiency was quantified as 40% and the final copolymer had double functionality, free amino groups and PNIPAAm segments on the side chains. Thanks to this, water solubility, pH and temperature sensitivity were achieved. The particle size of the aqueous solutions increased from 500 nm to 3.5 µm, with the increase of temperature from 25 to 50 °C. The lower critical solution temperature (LCST) of the solution was determined as 38-42 °C. CS-g-PNIPAAm could be used as a polymeric carrier within a pharmaceutical formulation for topical applications.

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“…19,20 Atom transfer radical polymerization (ATRP) has been the most used technique for CTS modification. 11,[21][22][23][24][25][26][27] CTS modification via reversible addition-fragmentation chain transfer (RAFT) [28][29][30] and nitroxide-mediated polymerization (NMP) [31][32][33][34] has also been reported. With respect to the use of NMP, CTS-TEMPO, obtained by functionalizing N-phthaloylchitosan with 4-OH-TEMPO through γ-radiation, was used as a macroalkoxyamine for the graft polymerization of styrene (ST) 31 and 4-styrenesulfonate (SS).…”

Section: Introductionmentioning

confidence: 99%