Synthesis and properties of thermo- and pH-sensitive poly(diallyldimethylammonium chloride)/poly(N,N-diethylacrylamide) semi-IPN hydrogel

Liu, Mingzhu; Liu, Hongliang; Ma, Liang; Gao, Chunmei; Zhu, Siying; Zhang, Shaopeng

doi:10.1016/j.cej.2010.02.034

Cited by 72 publications

(26 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Figure 1 shows the IR spectra of the monomers DEAAm, DMAAm and P(DEAAm-DMAAm) copolymer. The similarity of the backbone structure of both monomers is obvious, displaying characteristic peaks at 1648 cm −1 and 1607 cm −1 [7,24] in the DEAAm spectrum and exhibiting bands at 1646 cm −1 and 1610 cm −1 [25,26] in the DMAAm spectrum. These absorption bands are assigned to the C0O (carbonyl group) and the olefin C0C bond stretching vibration, respectively.…”

Section: Ftir Spectroscopymentioning

confidence: 95%

See 1 more Smart Citation

Photopolymerised thermo-responsive poly(N,N-diethylacrylamide)-based copolymer hydrogels for potential drug delivery applications

et al. 2012

View full text Add to dashboard Cite

Novel thermo-sensitive N,N-diethylacrylamide (DEAAm) based copolymer hydrogels were prepared via UV-induced free radical bulk polymerisation. UV polymerisation was employed to avoid the use of potentially toxic solvents; solution polymerisation has been the most common means for the preparation of PDEAAm-based hydrogels in the literature to date. The resultant hydrogels were analysed using nuclear magnetic resonance, Fourier transform infrared spectroscopy and modulated differential scanning calorimetry. Parameters such as the crosslinking degree and the nature of the incorporated hydrophilic component, N-vinyl-2-pyrrolidone (NVP) or N,N-dimethylacrylamide (DMAAm) were found to impact hydrogel structure, mechanical properties and swelling kinetics. Pulsatile swelling studies indicated that the hydrogels had thermo-reversible properties which were greatly affected by test temperature, nature of hydrophilic monomer used and crosslinker content. Aminophylline was selected as a model solute for drug loading and release studies by thermal deswelling in HCl buffer (pH 1.4) and phosphate buffer media (pH 6.8). The observed lag time prior to significant drug release from the more crosslinked P(DEAAm-NVP) hydrogels could make them suitable for delayed specific release in the intestine and potential alternatives to layers or membranes in timespecific and site-specific swelling-controlled drug delivery systems.

show abstract

Section: Ftir Spectroscopymentioning

confidence: 95%

“…6). Slower reswelling kinetics is a frequently reported phenomenon with temperature-sensitive hydrogels [24,30,48]. Upon handling, the mechanical strength of P(DEAAm-NVP) hydrogels appeared superior to that of the P(DEAAmDMAAm) samples (see "Rheometry" for quantitative analysis of the hydrogel strength).…”

Section: Phase Transition Determinationmentioning

confidence: 98%

Photopolymerised thermo-responsive poly(N,N-diethylacrylamide)-based copolymer hydrogels for potential drug delivery applications

et al. 2012

View full text Add to dashboard Cite

show abstract

“…On the other hand, different semi-IPN hydrogels of poly(diallyldimethylammonium chloride) / poly(N,N-diethylacrylamide) (PDADMAC/PDEA) were synthesized from DEA via free-radical polymerization in the presence of crosslinker and PDADMAC aqueous solution. [9] Due to the introduction of PDADMAC component, an interconnected porous structure was generated, and the states of water of PDEA hydrogel was affected. PDEA hydrogel is a typical thermosensitive polymeric network, which exhibits a VPTT about 31 °C.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Polymeric nanocomposites made of a conductive polymer and a thermosensitive hydrogel: Strong effect of the preparation procedure on the properties

Martínez

Abel

Rivero

et al. 2015

Polymer

View full text Add to dashboard Cite

“…PEG is a neutral, nontoxic, water-soluble polymer approved by the US Food and Drug Administration (FDA) for a variety of clinical uses, such as carrier and excipient in the pharmaceutical, cosmetic, and food products [5,11]. PEG has also been used in drug delivery, tissue engineering scaffolds, surface functionalization, and so forth [12,13].…”

Section: Introductionmentioning

confidence: 99%

“…The capability of water absorption (swollen weight per dry weight) depends on the porosity, cross-linking density, and chemical nature of the polymer chains carrying functional groups such as -NH 2 , -COOH, -CONH 2 , and -SO 3 H [2]. Hydrogels may be prepared so that their physical-chemical characteristics (e.g., equilibrium swelling and absorption kinetic) respond to changes in their external environment, such as temperature [3], pH [4,5], ionic strength [6], and so on. These materials show a wide variety of applications such as drug delivery [7], membranes for (bio)separation process [8], substrate for cell culture [9], and mucosal vaccines [10].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of a pH-responsive poly(ethylene glycol)-based hydrogel: acid degradation, equilibrium swelling, and absorption kinetic characteristics

et al. 2015

View full text Add to dashboard Cite

We developed a pH-responsive, hydrogel based on poly(ethylene glycol) (PEG) covalently cross-linked with acrylic acid and N′,N′-dimethylacrylamide along with acidlabile groups. In the hydrogel, PEG plays a role as the key constituent. If its chains break, the polymer networks are destroyed. The pharmacological potential of these hydrogels were demonstrated by determining their water transport profile, modulus of elasticity, and cytotoxicity assay. The hydrogels showed a pseudo-Fickian behavior, a transport mechanism that occurs when the diffusion coefficient changes with the time and the swelling equilibrium is never fully reached. At pH 2, the PEG-richer hydrogels degraded and the scanning electron microscopy (SEM) images illustrated less-defined shapes than at pH 7 and 10. This morphological characteristic results of the hydrogel deconstruction owing to cleavage of ether bonds of the PEG chains unmaking its 3D polymer network. The proposed hydrogels were shown to be compatible to cells, indicating acceptable biocompatibility and an appropriate level of security for use in the biological environments. Furthermore, they showed structural changes in their polymer network in response to pH, which is an important characteristic for stimuli-triggered release of guest molecules.

show abstract

Synthesis and properties of thermo- and pH-sensitive poly(diallyldimethylammonium chloride)/poly(N,N-diethylacrylamide) semi-IPN hydrogel

Cited by 72 publications

References 38 publications

Photopolymerised thermo-responsive poly(N,N-diethylacrylamide)-based copolymer hydrogels for potential drug delivery applications

Photopolymerised thermo-responsive poly(N,N-diethylacrylamide)-based copolymer hydrogels for potential drug delivery applications

Polymeric nanocomposites made of a conductive polymer and a thermosensitive hydrogel: Strong effect of the preparation procedure on the properties

Synthesis and characterization of a pH-responsive poly(ethylene glycol)-based hydrogel: acid degradation, equilibrium swelling, and absorption kinetic characteristics

Contact Info

Product

Resources

About