Synthesis and properties of some 2,3‐disubstituted 6‐fluoro‐7‐(4‐methyl‐1‐piperazinyl)quinoxalines

Abstract

The 2,3‐disubstituted 6‐fluoro‐7‐(4‐methyl‐1‐piperazinyl)‐quinoxalines (3–11) were synthesized for bioassay via reaction of 1.2‐diamino‐4‐fluoro‐5‐(4‐methyl‐1‐piperazinyl)benzene (2) with the appropriate 1,2‐dicarbonyl compounds. However, none of the tested compounds 3–11 showed significant in vitro activ ity against E. coli ATCC11229, S. aureus ATCC6538 and C.albicans SATCC10231.

Approaches to Open Fullerenes: Synthesis and Thermal Stability of cis-1 Bis(isobenzofuran) Diels−Alder Adducts of C60

“…Having successfully isolated the bis(isobenzofuran) cis-1 bisadduct 4b possessing the one-atom (CH 2 ) linker, we became interested in the possibility of forming bis(isobenzofuran) cis-1 bisadducts featuring longer linkers. After considering many of the options available for a two-atom tether, we chose to use the quinoxaline-2,3-diyl linker because 2,3-bisfurylquinoxaline can be readily prepared from commercially available furfural in a few steps and on a large scale . In principle, 2,3-bisfurylquinoxaline can be used as a building block for preparing a number of other bis(isobenzofuran) precursors because the C5 position of the furyl group is readily functionalized, e.g., through Vilsmeier−Haack formylation .…”

Novel Palladium(II) and Platinum(II) Complexes with a Fluoropiperazinyl Based Ligand Exhibiting High Cytotoxicity and Anticancer ActivityIn Vitro

“…4-Fluoro-5-(4-piperazinyl)-1,2-diaminobenzene has recently been proved to be a valuable intermediate for the synthesis of various benzimidazole derivatives of biological interest, for example, as anticancer agents and bactericides [17]. Furthermore, ferrocenyl-based complexes with 5-fluoro-6-(4-substituted-1-piperazinyl)benzimidazoles have been reported.…”

Design, Synthesis, and Cytotoxicity of 5-Fluoro-2-methyl-6-(4-aryl-piperazin-1-yl) Benzoxazoles

“…The introduction of fluorine and piperazine appendages played a vital role in enhancing the antimicrobial activities of the quinolone drugs, e.g., ciprofloxacin ® ( 1 ) (Figure 1), the most active antibiotic drug on the market [12]. Similarly, we have successfully synthesized a variety of heterocyclic systems incorporating fluorine and piperazine moieties, such as quinoxaline [13] ( 2 ), benzimidazole [14] ( 3 ), quinazolinone [15] ( 4 ), and recently benzothiazole [16] ( 5 ). Some derivatives of our systems showed very promising biological activities, which were attributed to the presence of both appendages.…”