Synthesis and properties of polyelectrolyte microgel particles

Nur, Hani; Pinkrah, V.T.; Mitchell, John C.; Benee, L. S.; Snowden, Martin J.

doi:10.1016/j.cis.2009.07.008

Cited by 31 publications

(24 citation statements)

References 25 publications

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“…By increasing temperature, contraction of the microgel particles takes place which results in the elimination of water from the interstitial spaces of the microgels and the polymer chain becomes more hydrophobic and polymer-solvent interactions are minimized. 15 From Figure 3 it is clear that hydrodynamic radius of the microgels containing 5 and 8 mol% MAA (2, 4 and 5% MBA) is dependent on temperature at pH 6.5 and underwent shrinking transition in the temperature range of 30~35 o C. It is seen that the shrinking transition was broader and shifted to higher temperature upon increasing the degree of crosslinking. Above the lower solution critical temperature (LCST), however, the swelling behavior decreased.…”

Section: Resultsmentioning

confidence: 88%

Preparation and Characterization of Novel Temperature and pH Sensitive (NIPAM-co-MAA) Polymer Microgels and Their Volume Phase Change with Various Salts

Khan¹,

Khan²,

Khan³

et al. 2013

Polymer Korea

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Novel microgels of N-isopropylacrylamide (NIPAM)-co-methacrylic acid (MAA) (NIPAM-co-MAA) with different contents of N,N-methylene bis acrylamide (MBA) were prepared by emulsion polymerization technique and were studied by Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS) and zeta potential measurement. Effect of pH, temperature and different salts concentration on the microgel particles was investigated. DLS results have shown that the hydrodynamic radius of the microgel increased upon increasing pH and decreased upon increasing temperature. The swelling/deswelling behaviors as determined by DLS showed the ionic repulsions of the carboxyl group of the methacrylic acid and hydrophobic interaction of NIPAM. The effect of various salts on volume phase transition temperature (VPTT) was also investigated. Upon increasing salt concentration, VPTT became broad and shifted to a lower temperature. Electrophoretic mobility measurements showed an increase with increasing pH and temperature at a constant ionic strength.

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Section: Resultsmentioning

confidence: 88%

Preparation and Characterization of Novel Temperature and pH Sensitive (NIPAM-co-MAA) Polymer Microgels and Their Volume Phase Change with Various Salts

Khan¹,

Khan²,

Khan³

et al. 2013

Polymer Korea

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show abstract

“…The polyelectrolyte solution was filtered by 220 nm filter membranes and was kept at a certain temperature for 10 min before tested. Mean diameters of the polyelectrolyte micelles at various temperatures in different PBS buffer solutions were determined by dynamic light scattering (Nano‐ZS, Malvern) 41. Nano‐ZS with backscatter detection was used for light scattering measurements with a detecting angle of 173°.…”

Section: Methodsmentioning

confidence: 99%

Synthesis, characteristics, and phase behavior of a thermosensitive and pH‐sensitive polyelectrolyte

Zhou

Gong

et al. 2011

J of Applied Polymer Sci

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A series of poly(N-isopropylacrylamide-comethacrylic acid-co-octadecyl acrylate) (poly(NIPAM-co-MAA-co-ODA)) with different monomer molar ratios was synthesized. Critical micelle concentration (CMC) of the polyelectrolyte solution was determined and the CMC increase with methacrylic acid content in the polyelectrolyte. The phase behaviors of the polyelectrolyte solution were studied, and the effects of various factors on the phase transition were discussed. The experimental results indicate that the lower critical solution temperature and the phase transition pH depend on the monomer molar ratio in the polyelectrolyte. Effect of polyelectrolyte concentration on phase transition pH was studied, and results shown that the phase-transition pH is independent of the polyelectrolyte concentration.

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“…PNIPA nanogel particles crosslinked by PEGDA were synthesized by surfactant-free dispersion polymerization (SFDP) in deionized water under an inert nitrogen atmosphere according to the procedure evaluated by Pelton and Chibante [21,22] and developed in the group of Lowe et al, and in other groups [23][24][25]. The radical initiator, ammonium persulfate, was placed in a 500 mL, three-necked round-bottomed flask and stirred continuously at 120 m −1 .…”

Section: Synthesis Of the Thermosensitive Nanoparticlesmentioning

confidence: 99%

Biphasic Equilibrium Dialysis of Poly(N-Isopropyl Acrylamide) Nanogels Synthesized at Decreased Temperatures for Targeted Delivery of Thermosensitive Bioactives

Musiał

Michálek

Pluta

et al. 2013

International Journal of Polymer Science

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Hydrogel nanoparticles, referred to also as nanogels, are of special interest for medical and pharmaceutical applications. Due to small size in the range below the diameter of the capillaries, they are proposed as drug delivery carriers. The aim of the study was to estimate the influence of composition and reaction conditions during synthesis of poly-N-isopropyl acrylamide cross-linked by polyethylene glycol diacrylate on the purification rates of the polymer. Six types of thermosensitive nanogels were prepared by surfactant-free dispersion polymerization and assessed in terms of process yield, composition, and size at temperatures below and over volume phase temperature. During the diffusion of impurities, in the course of dialysis, assessed by the conductometric method, the remarkable influence of temperature and initiator concentration on the process was revealed. The release rates varied in the range between 9.63 · 10−2and 1.39 · 10−1 h−1in the first stage of the process, whereas in the second stage they were between 2.09 · 10−2and 6.28 · 10−2 h−1. The evaluated time to obtain acceptable purity of the preparation was estimated to be in the range of 18 days. More detailed research should be directed towards the influence of the structure of obtained material on the purification process.

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Synthesis and properties of polyelectrolyte microgel particles

Cited by 31 publications

References 25 publications

Preparation and Characterization of Novel Temperature and pH Sensitive (NIPAM-co-MAA) Polymer Microgels and Their Volume Phase Change with Various Salts

Preparation and Characterization of Novel Temperature and pH Sensitive (NIPAM-co-MAA) Polymer Microgels and Their Volume Phase Change with Various Salts

Synthesis, characteristics, and phase behavior of a thermosensitive and pH‐sensitive polyelectrolyte

Biphasic Equilibrium Dialysis of Poly(N-Isopropyl Acrylamide) Nanogels Synthesized at Decreased Temperatures for Targeted Delivery of Thermosensitive Bioactives

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