Synthesis and properties of NTP analogs with modified triphosphate chains

The synthesis of 2′-methylseleno adenosine and guanosine 5′-triphosphates

“…The first chemical synthesis of NTPs was accomplished in 1949, 12 and ever since, diverse chemical approaches have been developed to effectively synthesize nucleoside triphosphates. 13–32 Due to the multiple functionalities of nucleosides, protection and deprotection of sugar hydroxyl and nucleobase amino groups has to be carefully considered in order to minimize the formation of by-products and regioisomers. Although challenging, one-pot procedures using minimally protected or completely unprotected nucleosides as substrates receive high attention and are a matter of continuous optimization.…”