Synthesis and properties of novel biodegradable triblock copolymers of poly(5-methyl-5-methoxycarbonyl-1,3-dioxan-2-one) and poly(ethylene glycol)

Zhou, Yu; Zhuo, Ren‐Xi; Liu, Zhilan

doi:10.1016/j.polymer.2004.06.016

Cited by 17 publications

(7 citation statements)

References 12 publications

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“…The relatively low thermal stability and poor mechanical properties associated with APCs have still limited them to applications that are less demanding in these properties in general. Of particular note, functional APCs with controlled architectures have been increasingly explored for biomedical applications in the last 2 decades, including as tissue engineering scaffolds in the form of electrospun fibers, biodegradable elastomers, hydrogels, and drug‐delivery carriers in the form of micelles, polymersomes, and polycomplexes . Here, we review some representative applications of APCs as hydrogels and drug‐delivery carriers.…”

Section: Applicationsmentioning

confidence: 99%

“…Indeed, there has been a surge of reports on APCs in the past 2 decades (Figure ); this has resulted from new progress on polymerization techniques, functional monomer syntheses, and the many new applications being explored . In this review, we first update the latest progress on APC polymerization techniques and new insights on traditional techniques applied to APC preparation and then discuss recent biomedical applications of APC‐based hydrogels and drug‐delivery carriers.…”

Section: Introductionmentioning

confidence: 99%

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Renaissance of aliphatic polycarbonates: New techniques and biomedical applications

Feng

Song

2013

J of Applied Polymer Sci

134

122

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Aliphatic polycarbonates were discovered a long time ago, with their conventional applications mostly limited to low molecular weight oligomeric intermediates for copolymerization with other polymers. Recent developments in polymerization techniques have overcome the difficulty in preparing high molecular weight aliphatic polycarbonates. These in turn, along with new functional monomers, have enabled the preparation of a wide range of aliphatic polycarbonates with diverse chemical compositions and structures. This review summarizes the latest polymerization techniques for preparing well-defined functional aliphatic polycarbonates, as well as the new applications of those aliphatic polycarbonates, esecially in the biomedical field.

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Section: Applicationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Renaissance of aliphatic polycarbonates: New techniques and biomedical applications

Feng

Song

2013

J of Applied Polymer Sci

134

122

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“…Saccharides play a central role in living systems due to their biological recognition, functional biomolecular and excellent biocompatibility. The combinations of carbohydrates with other specific molecules provide much opportunity for developing new drug types and improving diseases therapy effect [12][13][14][15][16][17][18]. A great number of drugs in use today rely on carbohydrates as their important parts.…”

Section: Introductionmentioning

confidence: 99%

Chemo-enzymatic synthesis and sustained release of optically active polymeric prodrugs of chlorphenesin

Quan

Zhu

et al. 2008

Polymer

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“…Different types of difunctional‐terminated macroinitiators (B block) can be used to form A–B–A triblock copolymers with different kinds of monomers. PCL/PEG/PCL,2–5 PLA/PEG/PLA,6–8 and poly(cyclic carbonate) (PCC)/PEG/PCC9, 10 have been synthesized from dihydroxyl‐terminated PEGs of different molecular weights with ϵ‐caprolactone (ϵ‐CL), lactide (LA), and cyclic carbonate, respectively. Meanwhile, PLA/PCL/PLA and poly(1,5‐dioxepan‐2‐one) (PDXO)/PCL/PDXO triblock copolymers have been prepared by the successive polymerization of CL and LA or 1,5‐dioxepan‐2‐one in the presence of ethylene glycol 11–13.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of biodegradable A–B–A triblock copolymers containing poly(ϵ‐caprolactone) A blocks and poly(trans‐4‐hydroxy‐L‐proline) B blocks

Lee¹,

Lin²,

Yang³

et al. 2006

J. Polym. Sci. A Polym. Chem.

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were synthesized by ring-opening polymerization from dihydroxyl-terminated macroinitiator poly(trans-4-hydroxy-N-benzyloxycarbonyl-L-proline) (PHpr) and e-caprolactone (e-CL) with stannous octoate as the catalyst. The molecular weights were characterized with gel permeation chromatography and matrix-assisted laser desorption/ionization timeof-flight mass spectrometry. With an increase in the contents of e-CL incorporated into the copolymers, a decrease in the glass-transition temperature (T g ) was observed. The T g values of copoly(4-phenyl-e-caprolactone) and copoly(4-methyl-e-caprolactone) were higher than T g of copoly(e-caprolactone). Their micellar characteristics in an aqueous phase were investigated with fluorescence spectroscopy, dynamic light scattering, and transmission electron microscopy. The block copolymers formed micelles in the aqueous phase with critical micelle concentrations in the range of 1.00-1.36 mg L À1 . With higher molecular weights and hydrophobic components in the copolymers, a higher critical micelle concentration was observed. As the feed weight ratio of antitriptyline hydrochloride (AM) to the polymer increased, the drug loading increased. The micelles exhibited a spherical shape, and the average size was less than 250 nm. The in vitro hydrolytic degradation and controlled drug release properties of the triblock copolymers were also investigated. V V C 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: [4268][4269][4270][4271][4272][4273][4274][4275][4276][4277][4278][4279][4280] 2006

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Synthesis and properties of novel biodegradable triblock copolymers of poly(5-methyl-5-methoxycarbonyl-1,3-dioxan-2-one) and poly(ethylene glycol)

Cited by 17 publications

References 12 publications

Renaissance of aliphatic polycarbonates: New techniques and biomedical applications

Renaissance of aliphatic polycarbonates: New techniques and biomedical applications

Chemo-enzymatic synthesis and sustained release of optically active polymeric prodrugs of chlorphenesin

Synthesis and characterization of biodegradable A–B–A triblock copolymers containing poly(ϵ‐caprolactone) A blocks and poly(trans‐4‐hydroxy‐L‐proline) B blocks

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