The reaction of bicyclo[2.2.1]hept-5-en-2-yl isocyanate with fl uoro-and chloro-substituted anilines was used to synthesize in a yield of 25-68% a series of 1,3-disubstituted ureas containing a lipophilic group in their structure. The synthesized ureas are promising as inhibitors of RNA virus replication and human soluble epoxide hydrolase.