Synthesis and Properties of Metal Phthalocyanines Containing Anthraquinone Chromophores

Rumyantseva, T. A.; Alekseeva, Anna A.; Tkachenko, M. A.

doi:10.1134/s107036322009011x

Cited by 1 publication

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is worth mentioning that although several metal complexes of adriamycin, daunorubicin, mitoxantrone, and their analogues with Fe(III), Al(III), Cu(II), Ni(II), Pd(II), and Tb(III) were prepared and characterized, ,− ,− comprehensive knowledge on structures of these metal complexes is lacking due to inherent difficulties in obtaining single crystals for X-ray diffraction studies. Single-crystal X-ray diffraction structures of only a few hydroxy-9,10-anthraquinone complexes are reported. ,, In this study also, different methods were employed to obtain single crystals of CoQ 3 taking different compositions of solvents.…”

Section: Introductionmentioning

confidence: 99%

A Co(III) Complex of 1-Amino-4-hydroxy-9,10-anthraquinone Exhibits Apoptotic Action against MCF-7 Human Breast Cancer Cells

et al. 2021

View full text Add to dashboard Cite

A Co(III) complex of 1-amino-4-hydroxy-9,10-anthraquinone (QH) (Scheme-1) having the molecular formula CoQ 3 (Scheme-2) was prepared and characterized by elemental analysis, FTIR spectroscopy, UV–vis spectroscopy, fluorescence spectroscopy, and mass spectrometry. In the absence of a single crystal, the energy-optimized molecular structure of CoQ 3 was determined by employing computational methods that was validated using spectroscopic evidences, elemental analysis, and mass spectrometry data. The electrochemical properties of the complex were analyzed using cyclic voltammetry and indicate a substantial modification of the electrochemical properties of the parent amino-hydroxy-9,10-anthraquinone. CoQ 3 was thereafter tested on MCF-7 human breast cancer cells. The IC 50 value for a 24 h incubation was found to be (95 ± 0.05) μg/mL. The study showed that such cancer cells underwent both early and late apoptosis following the interaction with CoQ 3 .

show abstract