Synthesis and properties of m‐ferrocenylbenzoylthiadiazole derivatives

Abstract

A series of m-ferrocenylbenzoylthiadiazole compounds, namely FcL 1 -FcL 7 , were synthesized using 3-ferrocenylbenzoic acid and 2-amino-5-aryl-1,3,4thiadiazole as raw materials. These compounds were characterized using infrared and NMR spectroscopies and elemental analysis. The crystal structure of FcL 7 was determined using X-ray diffraction. The electrochemical behaviors of FcL 1 -FcL 7 revealed that the redox reactions on the surface of electrodes were reversible with a single-electron mechanism. Also, FcL 1 -FcL 7 demonstrated certain redox responses to Pb 2+ and Zn 2+ . Moreover, FcL 5 -FcL 7 exhibited good inhibition against human esophageal cancer cells in anticancer activity tests.