Synthesis and Properties of Gelatin Methacryloyl (GelMA) Hydrogels and Their Recent Applications in Load-Bearing Tissue

Sun, Mingyue; Sun, Xiaoting; Wang, Ziyuan; Guo, Shuyu; Yu, Guangjiao; Yang, Haw

doi:10.3390/polym10111290

Cited by 288 publications

(249 citation statements)

References 106 publications

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“…To overcome this challenge, a material with a high swelling ratio is desired for ISF extraction by diffusion. GelMA was selected due to its biocompatibility and composition of primarily gelatin,47 a natural polymer already used in biomedical engineering applications in our previous studies, such as scaffolds,48 injectable hydrogels,49 drugs and growth factor carriers,50 and bioinks for 3D printing 51. We observed that the GelMA had swelling properties promising for the extraction of ISF.…”

Section: Figurementioning

confidence: 99%

Gelatin Methacryloyl Microneedle Patches for Minimally Invasive Extraction of Skin Interstitial Fluid

Zhu

Zhou

Kim

et al. 2020

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127

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The extraction of interstitial fluid (ISF) from skin using microneedles (MNs) has attracted growing interest in recent years due to its potential for minimally invasive diagnostics and biosensors. ISF collection by absorption into a hydrogel MN patch is a promising way that requires the materials to have outstanding swelling ability. Here, a gelatin methacryloyl (GelMA) patch is developed with an 11 × 11 array of MNs for minimally invasive sampling of ISF. The properties of the patch can be tuned by altering the concentration of the GelMA prepolymer and the crosslinking time; patches are created with swelling ratios between 293% and 423% and compressive moduli between 3.34 MPa and 7.23 MPa. The optimized GelMA MN patch demonstrates efficient extraction of ISF. Furthermore, it efficiently and quantitatively detects glucose and vancomycin in ISF in an in vivo study. This minimally invasive approach of extracting ISF with a GelMA MN patch has the potential to complement blood sampling for the monitoring of target molecules from patients.

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Section: Figurementioning

confidence: 99%

Gelatin Methacryloyl Microneedle Patches for Minimally Invasive Extraction of Skin Interstitial Fluid

Zhu

Zhou

Kim

et al. 2020

Small

127

130

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“…When exposed to light, it can be cross‐linked to form a hydrogel with adjustable mechanical properties. GelMA can also be mixed with nanoparticles and other polymers to form a hybrid hydrogel system with specific biological applications (Sun et al, 2018). Some researchers have used GelMA to add ADSCs to repair chronic tendon injuries (Rothrauff et al, 2019).…”

Section: T/l Tissue Engineeringmentioning

confidence: 99%

Injectable hydrogels for tendon and ligament tissue engineering

Liu

Zhang

Chen

2020

J Tissue Eng Regen Med

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The problem of tendon and ligament (T/L) regeneration in musculoskeletal diseases has long constituted a major challenge. In situ injection of formable biodegradable hydrogels, however, has been demonstrated to treat T/L injury and reduce patient suffering in a minimally invasive manner. An injectable hydrogel is more suitable than other biological materials due to the special physiological structure of T/L. Most other materials utilized to repair T/L are cell‐based, growth factor‐based materials, with few material properties. In addition, the mechanical property of the gel cannot reach the normal T/L level. This review summarizes advances in natural and synthetic polymeric injectable hydrogels for tissue engineering in T/L and presents prospects for injectable and biodegradable hydrogels for its treatment. In future T/L applications, it is necessary develop an injectable hydrogel with mechanics, tissue damage‐specific binding, and disease response. Simultaneously, the advantages of various biological materials must be combined in order to achieve personalized precision therapy.

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“…These modified ECMs can then be mixed with cells and crosslinked in the presence of UV light and a photoinitiator [24,25]. The stiffness of the hydrogel can be tuned by varying the UV exposure time and/or intensity, giving way to user-defined physical properties [26]. Some common examples of methacrylate-modified biomaterials are hyaluronic acid and gelatin (HAMA and GelMA, respectively).…”

Section: Influence Of Ecm Stiffness On Neural Fatementioning

confidence: 99%

Recent Advancements in Engineering Strategies for Manipulating Neural Stem Cell Behavior

O’Grady

Lippmann

2020

Curr. Tissue Microenviron. Rep.

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Purpose of Review Stem cells are exquisitely sensitive to biophysical and biochemical cues within the native microenvironment. This review focuses on emerging strategies to manipulate neural cell behavior using these influences in three-dimensional (3D) culture systems. Recent Findings Traditional systems for neural cell differentiation typically produce heterogeneous populations with limited diversity rather than the complex, organized tissue structures observed in vivo. Advancements in developing engineering tools to direct neural cell fates can enable new applications in basic research, disease modeling, and regenerative medicine. Summary This review article highlights engineering strategies that facilitate controlled presentation of biophysical and biochemical cues to guide differentiation and impart desired phenotypes on neural cell populations. Specific highlighted examples include engineered biomaterials and microfluidic platforms for spatiotemporal control over the presentation of morphogen gradients.

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Synthesis and Properties of Gelatin Methacryloyl (GelMA) Hydrogels and Their Recent Applications in Load-Bearing Tissue

Cited by 288 publications

References 106 publications

Gelatin Methacryloyl Microneedle Patches for Minimally Invasive Extraction of Skin Interstitial Fluid

Gelatin Methacryloyl Microneedle Patches for Minimally Invasive Extraction of Skin Interstitial Fluid

Injectable hydrogels for tendon and ligament tissue engineering

Recent Advancements in Engineering Strategies for Manipulating Neural Stem Cell Behavior

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