Synthesis and properties of cordycepin intercalates of Mg–Al–nitrate layered double hydroxides

Yang, Qin; Yang, Jing; Zhang, Chang Kai

doi:10.1016/j.ijpharm.2006.06.037

Cited by 36 publications

(26 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Protocatechuic acid (1.6 g, 0.2 M) was dissolved in 50 mL water and added to the aqueous solution containing 0.2 g Mg/Al-NO 3 . The pH of the reaction mixture was kept at 10 by the simultaneous addition of 2 M NaOH solution and the mixture was stirred vigorously for 2 hours at room temperature.…”

Section: Synthesismentioning

confidence: 99%

“…The FTIR spectrum of Mg/Al-LDH ( Figure 3B) shows a strong absorption band at 1385 cm -1 that can be attributed to the stretching vibration of NO 3 -. 40 In the lowfrequency region, the absorption peaks indicate that the lattice vibration modes can be attributed to M-O and O-M-O at 610 and 837 cm -1, respectively.…”

Section: Infrared Spectroscopymentioning

confidence: 99%

“…Among them are the cardiovascular drugs fluvastatin and pravastatin; 15 anti-inflammatory drugs such as diclofenac 16 and fenbufen; 17 antihypertensive drugs like perindopril erbumine; 18,19 the antihistamine drug cetirizine hydrochloric acid; 20 and anticancer drugs such as cordycepin, which was intercalated into the gallery of magnesium/ aluminum (Mg/Al)-LDH. It was observed that the resulting nanohybrid had greater stability and a greater suppression effect on U937 cancer cell growth than free cordecypin 3 and methotrexate (MTX). A MTX-Mg/Al nanohybrid had a much stronger inhibition effect on the proliferation of human MNNG-HOS osteosarcoma cancer cells compared with unbound MTX.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Preparation and controlled-release studies of a protocatechuic acid-magnesium/aluminum-layered double hydroxide nanocomposite

Barahuie¹,

Hussein²,

Hussein‐Al‐Ali³

et al. 2013

IJN

View full text Add to dashboard Cite

Abstract:In the study reported here, magnesium/aluminum (Mg/Al)-layered double hydroxide (LDH) was intercalated with an anticancer drug, protocatechuic acid, using ionexchange and direct coprecipitation methods, with the resultant products labeled according to the method used to produce them: "PANE" (ie, protocatechuic acid-Mg/Al nanocomposite synthesized using the ion-exchange method) and "PAND" (ie, protocatechuic acid-Mg/Al nanocomposite synthesized using the direct method), respectively. Powder X-ray diffraction and Fourier transform infrared spectroscopy confirmed the intercalation of protocatechuic acid into the inter-galleries of Mg/Al-LDH. The protocatechuic acid between the interlayers of PANE and PAND was found to be a monolayer, with an angle from the z-axis of 8° for PANE and 15° for PAND. Thermogravimetric and differential thermogravimetric analysis results revealed that the thermal stability of protocatechuic acid was markedly enhanced upon intercalation. The loading of protocatechuic acid in PANE and PAND was estimated to be about 24.5% and 27.5% (w/w), respectively. The in vitro release study of protocatechuic acid from PANE and PAND in phosphate-buffered saline at pH 7.4, 5.3, and 4.8 revealed that the nanocomposites had a sustained release property. After 72 hours incubation of PANE and PAND with MCF-7 human breast cancer and HeLa human cervical cancer cell lines, it was found that the nanocomposites had suppressed the growth of these cancer cells, with a half maximal inhibitory concentration of 35.6 μg/mL for PANE and 36.0 μg/mL for PAND for MCF-7 cells, and 19.8 μg/mL for PANE and 30.3 μg/mL for PAND for HeLa cells. No half maximal inhibitory concentration for either nanocomposite was found for 3T3 cells.

show abstract

Section: Synthesismentioning

confidence: 99%

Section: Infrared Spectroscopymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preparation and controlled-release studies of a protocatechuic acid-magnesium/aluminum-layered double hydroxide nanocomposite

Barahuie¹,

Hussein²,

Hussein‐Al‐Ali³

et al. 2013

IJN

View full text Add to dashboard Cite

show abstract

“…LDHs are a class of host-guest layered solids with the general formula M 21 and M 31 are divalent and trivalent metal cations, respectively [2], with A n2 being an interlayer anion [3] with the negative charge. The interlayer anion exchangeable capability of LDHs meets the requirement of inorganic matrices for encapsulating functional biomolecules of negative charge in aqueous media [4], where "m" is the number of interlayer water [5] and "x" the charge density, equal to the molar ratio, M 31 /(M 21 1 M 31 ). LDHs have many properties which make them attractive for real applications; including nanomedicine, adsorbents, catalyst supports controlled release of anions and, antacids.…”

Section: Introductionmentioning

confidence: 99%

Bionanocomposites based on alginate and chitosan/layered double hydroxide with ciprofloxacin drug: Investigation of structure and controlled release properties

Rezvani

Shahbaei

2014

Polymer Composites

View full text Add to dashboard Cite

In this research work, the antibiotic drug Ciprofloxacin (CFX) was intercalated into interlayer space of Zn/Al layered double hydroxides (LDH) by coprecipitation method and CFX-LDH nanohybride was obtained. Then, the Alginate/LDH and Chitosan/LDH bionanocomposites were prepared by coating of CFX-LDH nanohybride with Alginate and Chitosan. The LDH-CFX nanohybride and the bionanocomposites were characterized using the powder X-ray diffraction, the scanning electron microscope, the thermogravimetric analyses, and the Fourier transform infrared spectroscopy. In vitro release behavior of the CFX from LDH and bionanocomposites is observed in buffer solution under pH conditions (pH 5 1.2, 6.8, 7.4) which have been chosen from a model of the passage materials through the gastrointestinal tract. POLYM. COMPOS., 00:000-000,

show abstract

“…[18][19][20] Nowadays LDHs are also used as supports in bionanocomposites for medical applications. 21,22 Therefore we decided to investigate the adsorption of arsenic from groundwater samples from Eastern Croatia on MgAl layered double hydroxide and to compare it with the adsorption of model arsenic samples on the same substrate. Additionally, the aim of the study was to examine the influence of phosphate concentration on adsorption of commercially obtained arsenic samples.…”

Section: Introductionmentioning

confidence: 99%

Adsorption of Arsenic on MgAl Layered Double Hydroxide

et al. 2013

View full text Add to dashboard Cite

Abstract. Groundwater in the Eastern Croatia, as well in the South-eastern Hungary, contains relatively high concentrations of arsenic that can cause chronic toxicity to humans. Therefore, the aim to find an effective composite adsorbent that can be applied for arsenic water remediation by introducing it in the groundwater treatment is very important. The presented results were obtained using layered double hydroxide (LDH) as a sorbing system. MgAl LDH samples with a Mg:Al molar ratio of 2:1 were synthesized. Adsorption of arsenic anions from groundwater samples from Eastern Croatia, as well as adsorption of model aquatic arsenic sample solutions, on MgAl layered double hydroxide was investigated. Inductively coupled plasma atomic emission spectrometry (ICP-AES) was used for determination of arsenic concentration after adsorption. It was shown that in both cases the adsorption process could be interpreted in terms of Kroeker adsorption isotherm regardless to the presence of other ions in the groundwater. Additionally, the influence of phosphate concentration on adsorption of model arsenic samples was examined and it was shown that (at least in examined range of arsenic and phosphate concentration) there is no significant influence of phosphate on adsorption of arsenic.

show abstract

Synthesis and properties of cordycepin intercalates of Mg–Al–nitrate layered double hydroxides

Cited by 36 publications

References 24 publications

Preparation and controlled-release studies of a protocatechuic acid-magnesium/aluminum-layered double hydroxide nanocomposite

Preparation and controlled-release studies of a protocatechuic acid-magnesium/aluminum-layered double hydroxide nanocomposite

Bionanocomposites based on alginate and chitosan/layered double hydroxide with ciprofloxacin drug: Investigation of structure and controlled release properties

Adsorption of Arsenic on MgAl Layered Double Hydroxide

Contact Info

Product

Resources

About