Synthesis and properties of CO₂-switchable Dex-g-PAHMA copolymers

Abstract

CO2-switchable Dex-g-PAHMA copolymers were synthesized and characterized. The properties of the graft copolymers and the cytotoxicity and cellular uptake of DOX-loaded Dex-g-PAHMA copolymer micelles were investigated.

CO2-responsive polymeric materials: synthesis, self-assembly, and functional applications

“…Therefore, the total amount of charge available for particle stabilization was limited, with the result being the solid content could not be increased to more than B7%. 194 Following synthesis of the monomer, (N-amido)hexyl methacrylamide (HMA), the FRP of HMA and dextran was performed in aqueous solution using potassium persulfate initiator at 50 1C. Addition of 0.54 mol% of DEAEMA, as a CO 2 -switchable comonomer, led to a significant increase in the achievable solids content to 27%.…”

“…133 CO 2 -switchable dextran-graft-poly((N-amidino)hexyl methacrylamide), (Dex-g-PAHMA), copolymers were prepared by FRP. 194 Following synthesis of the monomer, (N-amido)hexyl methacrylamide (HMA), the FRP of HMA and dextran was performed in aqueous solution using potassium persulfate initiator at 50 1C. The product was purified by dialysis and the resulting solution lyophilized to obtain purified copolymer.…”

Amphiphilic block copolymer terminated with pyrene group: from switchable CO2-temperature dual responses to tunable fluorescence

“…26 As a result, it is very important to explore more general, robust, and efficient approaches to enable the use of CO 2 as a trigger for a broad range of polymers and materials. [27][28][29][30] Zhao et al discovered that poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) can react directly with CO 2 in water without functionalisation with amidine, which can drastically increase its lower critical solution temperature (LCST), characterizing the transition from a soluble (hydrated) to an insoluble (dehydrated) state. 31 The change in LCST is reversible upon removal of CO 2 using Ar.…”

Facile Synthesis of CO2‐Responsive Nano‐Objects: Batch versus Semi‐Batch RAFT Copolymerization

“…Carbon dioxide (CO 2 ), which is a benign, green, cost‐effective, abundant, biocompatible, and non‐toxic trigger for stimuli‐responsive polymers, has received much attention over the last decade. [ 1–4 ] Due to the very interesting properties of CO 2 as a trigger, CO 2 ‐responsive polymers have found great potential applications in different areas including latexes, [ 5 ] fibers, [ 6 ] gels, [ 7 ] surfactants, [ 8 ] self‐assemblies, [ 1 ] drug carriers, [ 9 ] and so on. [ 10–12 ] As we all know, statistical and block copolymers are widely used for CO 2 ‐responsive polymers since the monomer composition profiles can be easily regulated through batch or stepwise monomer feeding method.…”