Synthesis and Properties of Biodegradable Hydrogel Based on Polysaccharide Wound Dressing

Abstract

The metabolic disorder of the wound microenvironment can lead to a series of serious symptoms, especially chronic wounds, which result in significant pain in patients. At present, there is no effective and widely used wound dressing. Therefore, it is important to develop new multifunctional wound dressings. Hydrogel is an ideal wound dressing for medical nursing because of its abilities to absorb exudate and maintain wound wetting, its excellent biocompatibility, and its ability to provide a moist environment for wound repair. Because of these features, hydrogel overcomes the shortcomings of traditional dressings. Therefore, hydrogel has high medical value and is widely studied. In this study, a biodegradable hydrogel based on polysaccharide was synthesized and used as a wound dressing. The swelling degree and degradability of hydrogel were characterized as the characteristics of the wound dressing. The results showed that the prepared hydrogel was degraded with trypsin and in the soil environment. Furthermore, the wound dressing can effectively inhibit the bacterial environment, promote the deposition of the collagen structure of the wound tissue, and accelerate the healing of the wound. The proposed hydrogel has value in practical medical nursing application.

Construction of self‐healing gallium (III)‐cross‐linked konjac glucomannan/polyacrylamide hydrogels for efficiently killing bacteria and accelerating wound healing

“…The appropriate degradation properties of hydrogels are critical for biological applications 38 . Therefore, the degradation experiments were conducted to estimate the weight remaining ratios ( R wr ) of KGM/PAM/Ga 3+ hydrogels.…”

“…The appropriate degradation properties of hydrogels are critical for biological applications. 38 Therefore, the degradation experiments were conducted to estimate the weight remaining ratios (R wr ) of KGM/PAM/Ga 3+ hydrogels. The R wr of K-x-P-Ga-0 hydrogels was approximate 34.0-37.5% after immersing in PBS (pH 7.2) for 72 h (Figure S3a), indicating the poor stability of KGM/PAM hydrogels.…”

Fabrication of a photothermal antibacterial platform for bacterial infectious skin wound healing: a review

“…The main function of traditional dressings is to absorb exudates and fluids of wounds. [64][65][66] However, owing to the difficulty in maintaining a moist wound environment, traditional dressings easily stick to the wound surface. This will cause secondary injury without an antibacterial effect.…”

Chitosan-based pH responsive hemostatic hydrogel loaded with cattail pollen

“…Natural biomass extracts have become a good alternative to organic polymers due to their excellent biodegradability, biocompatibility, and low cost [7][8] . Shao et al [9] prepared a biodegradable wound dressing based on polysaccharides, which effectively avoided the irritation problem of traditional dressings and provided ideas for wound healing. Wan et al [10] loaded emodin, a natural herbal ingredient, into the chitosan-based hydrogel to improve the healing effect of the hydrogel.…”