Synthesis and properties of biodegradable chitin‐<i>graft</i>‐poly(<scp>L</scp>‐lactide) copolymers

Kim, Ji Young; Ha, Chang Sik; Jo, Nam‐Ju

doi:10.1002/pi.1000

Cited by 38 publications

(22 citation statements)

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“…Thus, chitin nanofibers and nanowhiskers have been applied as a useful reinforcing elements to improve the mechanical properties of acrylic resins [122], polylactide [123] and poly(ε-caprolactone) [124,125].…”

Section: Mechanical Stability Of Chitin-based Materialsmentioning

confidence: 99%

Poriferan Chitin as a Versatile Template for Extreme Biomimetics

et al. 2015

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Abstract:In this mini-review, we shall first cover a short history of the discovery of chitin isolated from sponges; as well as its evolutionarily ancient roots. Next, we will delve into the unique structural, mechanical, and thermal properties of this naturally occurring polymer to illuminate how its physicochemical properties may find uses in diverse areas of the material sciences. We show how the unique properties and morphology of sponge chitin renders it quite useful for the new route of "Extreme Biomimetics"; where high temperatures and pressures allow a range of interesting bioinorganic composite materials to be made. These new biomaterials have electrical, chemical, and material properties that have applications in water filtration, medicine, catalysis, and biosensing. OPEN ACCESSPolymers 2015, 7 236

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Section: Mechanical Stability Of Chitin-based Materialsmentioning

confidence: 99%

Poriferan Chitin as a Versatile Template for Extreme Biomimetics

et al. 2015

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“…19 In addition, TEA attacks the carbonyl group in lactone, rendering it a carbocation, which can be readily attacked by nucleophiles. 18,20 The role of TEA in the reaction is to lower the activation energy for the formation of the carbocation. This translates to a shortening of the reaction time.…”

Section: Synthesis and Characterization Of Pupl Copolymermentioning

confidence: 99%

“…18,19 When TEA is used as a catalyst, PLLAgrafted chitin/chitosan copolymers can be readily synthesized via ring-opening polymerization. 20,21 Thus, the synthesis of the lactide derivatives of other polysaccharides via this method is anticipated.…”

Section: Introductionmentioning

confidence: 99%

Self‐organized nanogels from pullulan‐g‐poly(L‐lactide) synthesized by one‐pot method: Physicochemical characterization and in vitro doxorubicin release

Cho

Park

2009

J of Applied Polymer Sci

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Water-insoluble pullulan-g-poly(L-lactide) (PUPL) was successfully synthesized via a one-pot method in the presence of triethylamine in dimethyl sulfoxide, in an effort to design a novel anticancer agent carrier. Three samples (designated as PUPL 1, 2, and 3) were obtained, which differed in the moles of lactides grafted to the pullulan. The degrees of grafted lactide per 1 glucose unit in pullulan were 0.68, 0.60, and 0.45 for PUPL 1, 2, and 3, respectively. These copolymers were dissolved in several organic solvents, including dimethyl sulfoxide, acetone, and ethanol, but were insoluble in water. The self-organized nanogels were then prepared from the polymers via dialysis. To study the organizing behavior of the polymers, their critical association concentrations were measured. Their values were 5.0, 15.9, and 52.9 mg/L for PUPL 1, 2, and 3, respectively. The results showed that lactide in the polymers could function as a hydrophobic moiety for the formation of selforganized nanogels. To estimate the potential of PUPL 1 as an anticancer drug carrier, we used doxorubicin (DOX) as a model drug. The DOX loading efficiencies of PUPL 1 were more than 52%, which differed with differing initial DOX concentrations. High loading resulted in slower DOX release as the result of increases in hydrophobic interaction.In conclusion, PUPL nanogels may prove useful as anticancer drug carriers because of their low critical association concentrations and the controlled DOX release rate V

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“…13 C NMR spectra obtained for the chitin-based PU samples (XRPU6), exhibited peaks at 23.0 and 174 ppm, which were attributed, respectively to the CH 3 (methyl) and C O (carbonyl) group of chitin [11]. Moreover, peaks located at about 56.2, 63.3, 69.6, 68.8, 77.5 and 104 ppm were attributed to C2, C6, C3, C5, C4 and C1 positions of chitin respectively [22,23], which provides evidence of involvement of chitin in final polyurethane structure (XRPU6). …”

Section: Molecular Characterizationmentioning

confidence: 99%