Synthesis and properties of an acid-labile dual-sensitive ABCD star quaterpolymer

Pan, Weidong; Liu, Huanhuan; Zhang, Hongcan; Zhao, Youliang

doi:10.1039/c6py00267f

Cited by 11 publications

(4 citation statements)

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“…Polymer topology has been recognized as a critical factor significantly influencing polymer properties in bulk and in solution among other factors including composition and molecular weight. − In fact, a variety of cyclic, star, dendritic, and interlocked polymers have been synthesized. In light of dynamic polymer structure control, the development of topology-transformable polymers which can change their topology in response to a particular stimulus, is attractive from the viewpoints of controlling polymer structure and properties, development of stimuli-responsive polymers, and so on. − …”

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confidence: 99%

Synthesis and Star/Linear Topology Transformation of a Mechanically Linked ABC Terpolymer

2016

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The synthesis of an ABC star terpolymer containing one polymer chain connected mechanically through a rotaxane linkage and its topology transformation to a linear structure are reported. Pseudo[2]rotaxane, which was designed as the key trifunctional species for the star polymer synthesis, comprised a sec-ammonium axle with ethynyl and hydroxy groups and a crown ether wheel with a trithiocarbonate group. Stepwise polymer connections to the pseudo[2]rotaxane using the three groups afforded a rotaxane-linked ABC star terpolymer. The topology transformation from star to linear by the removal of the attractive interaction between the axle and wheel components yielded a linear ABC terpolymer via the wheel shifting to the axle end. The spectroscopic and solution property changes clearly indicated the occurrence of the polymer topology change.

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confidence: 99%

Synthesis and Star/Linear Topology Transformation of a Mechanically Linked ABC Terpolymer

2016

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“…2,2′-azobis (isobutyronitrile) (AIBN) was recrystallized twice from ethanol. Prop-2-ynyl-3-(5-cyano-5-phenylthiocarbonylsulfanyl) pentanoyloxy-2-(2,2-dihyd -roxymethyl)-propionyloxymethyl-2-methylpropanoate (PCBP) was prepared and purified in reference to literature procedures [30].…”

Section: Methodsmentioning

confidence: 99%

Amphiphilic Block Copolymer Poly (Acrylic Acid)-B-Polycaprolactone as a Novel pH-sensitive Nanocarrier for Anti-Cancer Drugs Delivery: In-vitro and In-vivo Evaluation

et al. 2019

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Gambogenic acid (GNA) has been demonstrated with outstanding antitumor activity as a potential antitumor drug in recent years. However, the low solubility and deficient bioavailability of GNA seriously hinder its practical application in the clinic area. In this study, a novel amphiphilic block copolymer, poly (acrylic acid)-b-polycaprolactone (PAA-b-PCL) is prepared and assembled into pH-responsive polymeric micelles (PMs) as one mold of drug delivery system (DDS) with unique properties. Relevant investigation on PMs exhibits excellent carrying potential and pH-dependent release performance for GNA. The drug loading capacity (DLC) and drug loading efficiency (DLE) for GNA-loaded PMs can be achieved as high as 15.20 ± 0.07% and 83.67 ± 0.49%, respectively. The in vitro experiments indicate that the GNA releasing time, cytotoxicity, and cellular uptake are significantly enhanced. Especially, the peak concentration (Cmax) and area under the curve (AUC) are promoted sharply in the GNA-loaded PMs concentration-time curve. This study not only provides a novel way to widen the application of anticancer GNA in the future, but also extends the potential of stimuli-responsive copolymers to biomedical applications.

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“…Furthermore, post-polymerization modification (PPM) 25,26 was used for the first time to prepare lipo-glycopolymers. A series of such polymers can be prepared from well-defined precursors.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of lipo-glycopolymers for cell surface engineering

et al. 2016

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Synthesis and properties of an acid-labile dual-sensitive ABCD star quaterpolymer

Abstract: Copolymer aggregates formed from an amphiphilic ABCD star could exhibit acid-induced topological and morphological transformations and stimuli-triggered drug delivery properties.

Cited by 11 publications

References 89 publications

Synthesis and Star/Linear Topology Transformation of a Mechanically Linked ABC Terpolymer

Synthesis and Star/Linear Topology Transformation of a Mechanically Linked ABC Terpolymer

Amphiphilic Block Copolymer Poly (Acrylic Acid)-B-Polycaprolactone as a Novel pH-sensitive Nanocarrier for Anti-Cancer Drugs Delivery: In-vitro and In-vivo Evaluation

Synthesis of lipo-glycopolymers for cell surface engineering

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