Synthesis and properties of alkoxyethyl 2-acetamido-2-deoxy- α - D -glucopyranoside

Solution Properties of Alkyl β‐D‐Maltosides

“…There are several methods including obtaining the HLB number (Ben‐et and Tartarsky, ; Berger et al, ; Ji et al, ; Zheng et al, ; Zhou et al, ; Zhou and Cui, ). Table and Fig.…”

“…Method 1 : According to Griffin's method (Ji et al, ), the HLB number of β‐D‐maltoside ( 6a – 6i ) was calculated by Eq. : where W is the molecular mass (341.29) of the hydrophilic sugar headgroup for β‐D‐maltoside ( 6a – 6i ); O is the molecular mass of the lipophilic alkyl group.…”

“…According to the literature method (Chen et al, 2016a;Ji et al, 2017), the solubility of alkyl β-D-maltoside (6a-6i) was determined at 25 C in water, ethanol, and ethyl acetate, respectively.…”

“…To date, it is one of the most significant properties of a surfactant. There are several methods including obtaining the HLB number (Ben-et and Tartarsky, 1972;Berger et al, 2005;Ji et al, 2017;Zheng et al, 2007;. Table 4 and Fig.…”

Self-Assembly of Amphiphilic Compounds as a Versatile Tool for Construction of Nanoscale Drug Carriers

“…Interestingly, the selection of functionalization of glucose-containing amphiphilic compounds and using of various approaches to molecule design could become a useful tool for tailoring desired practical properties. For example: (i) significant foamability and high emulsion stability for toluene/water system could be achieved in the case of application of amido- and/or alkoxy derivatives of this hexose [ 52 ]; (ii) introduction of a trisiloxane fragment into the glucose structure is responsible for superspreading properties on hydrophobic surfaces like parafilm [ 53 ]; (iii) the transition from monomeric amphiphiles to their gemini analogues containing two glucose fragments and additional OH-groups is key for the construction of vehicles for biomedicine purposes capable of effectively encapsulating the drug of a broad spectrum, resveratrol (encapsulation efficiency reaches 90%) [ 54 ], and amino acids with demonstrated of chiral specificity toward certain D- or L-isomers [ 55 ]; (iv) thermotropic liquid crystalline behavior can be achieved in the case of sulfur-containing glucose derivatives [ 56 ]. The utilization of other monosaccharides as building blocks for amphiphilic compounds is also well-known, however these reports are significantly fewer: mannose derivatives are documented as agents for regulating the aggregation state of β-lactoglobulin [ 57 ], and a xylopyranose-based amphiphilic compound shows itself as a material for the construction of liquid crystals [ 58 ].…”