Synthesis and properties of 1-aroyl-5,5-dialkyl-2,3,5,6-tetrahydropyrrolo[ 2,1-a]isoquinoline-2,3-diones

I2-DMSO-Mediated N–H/α-C(sp3)–H Difunctionalization of Tetrahydroisoquinoline: Formal [2 + 2 + 1] Annulation for the Construction of Pyrrolo[2,1-a]isoquinoline Derivatives

“…Through retrosynthetic analysis of these skeletons, one of the main synthetic methods is closure of the pyrrole ring based on isoquinoline derivatives . The traditional method is to react oxalyl chloride with an isoquinoline derivative prepared from 2-phenylethylamine by the N–H functionalization strategy . Recently, the development of the C–H bond functionalization of amines continues to be a topic of significant interest, and the C–H functionalization reaction of amines that features azomethine ylide intermediates has been widely applied in complex target synthesis .…”