Synthesis and preparation of biocompatible and pH-responsive cyclodextrin-based nanoparticle

Hu, Xiaohong; Chen, Shangneng; Gong, Xiao; Gao, Ziyu; Wang, Xin; Chen, Pin

doi:10.1007/s11051-017-3819-5

Cited by 15 publications

(30 citation statements)

References 29 publications

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“…In the first step, acetylated β-CD (Ac-β-CD) was synthesized according to acetylation reaction [15]. Briefly, 20 times of 2-methoxypropene was reacted with β-CD in anhydrous DMSO for 1 h at 30°C and catalyzed by 5 mM pyridinium p-toluene sulfonate.…”

Section: Synthesis Of Magnetic and Ph-sensitive Compositementioning

confidence: 99%

“…However, in most cases, traditional natural polymers lacked of a responsive functional group that response to external stimulus, which restricted their application. Recently, the emerging of acetylated polysaccharides, which had response to acid environment (pH 5.5-6.0) due to the dissolution of acetylated groups, changed the situation [7,14,15]. Thus, in the recent research including our own research, the acetylated materials have been intensively concerned and prepared to various carriers including nanoparticle, composite nanocarrier, and nanofiber for drug delivery, gene delivery, and RNA delivery [7,14,15].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, the emerging of acetylated polysaccharides, which had response to acid environment (pH 5.5-6.0) due to the dissolution of acetylated groups, changed the situation [7,14,15]. Thus, in the recent research including our own research, the acetylated materials have been intensively concerned and prepared to various carriers including nanoparticle, composite nanocarrier, and nanofiber for drug delivery, gene delivery, and RNA delivery [7,14,15]. Although these acid-responsive nanocarriers had succeeded to realize the effective delivery of drug to intracell or abnormal tissue, they were hardly delivered to targeted cell or tissue on the account of lacking the antibody recognition system or targeting system.…”

Section: Introductionmentioning

confidence: 99%

“…But pure Fe 3 O 4 nanoparticle is easy to aggregate and lacks biocompatibility. Thus, surface modification using functional polymers was often used to enhance their biocompatibility and improve their dispersibility [15]. In view of their good biocompatibility and natural biodegradability, natural amphiphilic compounds were ideal modifiers for the surface modification of Fe 3 O 4 nanoparticle.…”

Section: Introductionmentioning

confidence: 99%

“…In the field of drug delivery, β-cyclodextrin (β-CD) has been intensively used because inclusion effects between β-CD molecules and drug molecules could help drug loading and control drug releasing [15,18,19]. Based on these foundations, biocompatible acetylated β-CD (Ac-β-CD) nanoparticle was previously synthesized and fabricated by a single microemulsion evaporation method using gelatin as an emulsifier, which endowed the biocompatibility to nanoparticle.…”

Section: Introductionmentioning

confidence: 99%

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A Magnetic and pH-Sensitive Composite Nanoparticle for Drug Delivery

Wang

Gao

Zhang

et al. 2018

Journal of Nanomaterials

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Mild acid response nanocarriers have been intensively attracted interest in the field of drug delivery on the account of the responsive property to abnormal physiological environment as well as the original property to normal physiological environment. However, the drug delivery system lacks capacity of precise localization to abnormal tissue or targeted cells. Therefore, a magnetic and pHsensitive composite nanoparticle was designed and prepared by double water-in-oil-in-water (W/O/W) emulsion using acetylated β-cyclodextrin (Ac-β-CD) as a dominant material to realize the pH response and Fe 3 O 4 as a component to realize magnetic response. The surface chemical characteristic was characterized by Fourier-transformed infrared spectroscopy (FTIR) using pure Ac-β-CD nanoparticle as a control and exhibits the typical chemical characteristic of Ac-β-CD. Furthermore, the structural information was tracked by X-ray diffraction (XRD) and thermogravimetric analysis (TG). It was found that composite nanoparticle possessed structural characteristic of both Ac-β-CD and Fe 3 O 4 . Composite nanoparticle exhibited sphere and two-phase morphology with the diameter of about 200-250 nm depending on their detection method and zeta potential of −12 to −14 mV. More importantly, irreversible pH response property and reversible magnetic responsive properties either in neutral environment or in mild acid environment for the composite nanoparticle were confirmed in the research. Finally, drug loading and release behavior were investigated through preliminary in vitro evaluation.

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Section: Synthesis Of Magnetic and Ph-sensitive Compositementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Magnetic and pH-Sensitive Composite Nanoparticle for Drug Delivery

Wang

Gao

Zhang

et al. 2018

Journal of Nanomaterials

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Characterization of zinc oxide nanocrystals with different morphology for application in ultraviolet‐light photocatalytic performances on rhodamine B

Bhunia

Saha

2020

Luminescence

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ZnO nanostructures of different morphology (nanorods, nano‐leaf, nanotubes) were favourably grown using a chemical precipitation process. The prepared ZnO nanostructures were characterized systematically using absorption spectroscopy, emission spectroscopy, X‐ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared studies. XRD results showed the hexagonal wurtzite phase of the synthesized ZnO nanostructures. Structural properties such as average crystallite size, lattice constants, volume of the unit cell, atomic fraction, and structural bonds were also studied. The optical band gap of the synthesized ZnO nanocrystals varied from 3.52 eV to 3.69 eV with high quantum yield of the blue emission (~420 nm). Urbach energy for ZnO nanocrystals was calculated to be 0.702 eV, 0.901 eV, and 0.993 eV for nanorods, nano‐leaf, and tube like ZnO crystals, respectively. Morphology of the fabricated nanostructures was investigated using SEM. Photocatalytic degradation of rhodamine B (Rh B) in solution under UV irradiation was explored with different ZnO morphology. Photocatalytic experiments showed that ZnO nano‐leaf had a higher degradation rate of photocatalytic activity of photodegrading Rh B compared with the other tube shape and rods shape nanostructures. The Rh B dye degraded considerably by ∼79.05%, 74.41%, and 69.8% within 120 min in the presence of the as‐fabricated fern nano‐leaf, nanotubes, and nanorods of the ZnO nanocrystals at room temperature.

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Polysaccharide Based Nanoparticles

Khan

Abtew

Modani

et al. 2018

Israel Journal of Chemistry

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Nanoparticles made of biodegradable polymers have outstanding merits as a drug delivery system. Polysaccharide-based nanoparticles have been well explored because of their safety, stability, biocompatibility, biodegradability and hydrophilicity. The present review emphasizes the efforts articulated to improve polysaccharide-based nano-particles as drug delivery tool for effective therapy and sitespecific targeting of mainly anticancer agents. This review updates reports of recent research on polysaccharides-based systems particularly chitosan, alginate, cyclodextrins, hyaluronic acid, pullulan, dextran and their combinations with potential applications.

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Synthesis and preparation of biocompatible and pH-responsive cyclodextrin-based nanoparticle

Cited by 15 publications

References 29 publications

A Magnetic and pH-Sensitive Composite Nanoparticle for Drug Delivery

A Magnetic and pH-Sensitive Composite Nanoparticle for Drug Delivery

Characterization of zinc oxide nanocrystals with different morphology for application in ultraviolet‐light photocatalytic performances on rhodamine B

Polysaccharide Based Nanoparticles

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