Synthesis and preliminary evaluation of the new water-soluble radioactive platinum(IV) complexes

Garnuszek, Piotr; Maurin, Michał; Skierski, Janusz; Koronkiewicz, Mirosława; Witowska-Jarosz, Janina

doi:10.1016/j.jinorgbio.2003.12.021

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“…111 A new class of water-soluble Pt(IV) complexes with histamine and radioiodinated histamine ([ 125 I/ 131 I]Hist) has been synthesised with the goal of potential application for concomitant anticancer radio-chemotherapy of solid tumours. 112 Several oestrogen-tethered platinum(IV) complexes were prepared and the potential of compounds of this class for treating breast and ovarian cancer was discussed. 113 In a panel of human tumour cells, trans Pt(II)-iminoether compounds were more effective than transplatin at inhibiting growth.…”

Section: Platinummentioning

confidence: 99%