Synthesis and preliminary evaluation of difluorinated 1,3-propanediones as potential agents in the treatment of breast cancer

Abstract

A series of difluorinated propanediones were synthesized and evaluated for in vitro cytotoxic activity by Sulforhodamine B (SRB) assay against a panel of four human cancer cell lines. Though the compounds showed varying degrees of cytotoxicity in the tested cell lines, most marked effect was observed in breast cancer cell line (MCF7), wherein nine of the ten synthesized chalcones showed good antiproliferative activity.

Current research on anti-breast cancer synthetic compounds

“…4). 107 Ortho-, meta-and para-tyrosine-chlorambucil analogs were synthesized in order to generate new anticancer drugs with structural diversity. The m-tyrosine-chlorambucil hybrids (119 and 120) showed greater cytotoxicity compared to the other regioisomers (Fig.…”

Design, in silico studies, synthesis, and in vitro anticancer assessment of new naphthylidene isoxazolidinedione derivatives

“…[5][6][7][8][9][10][11][12][13][14][15] However, we also published compounds without the TZD nucleus showing good antiproliferative activity (Figure 1). [16][17][18][19][20][21][22][23][24][25] Interestingly, there are countless pieces of literature demonstrating compounds with anticancer activity incorporating various heterocyclic rings. 17,19,[25][26][27][28][29][30] On a similar path, we have recently reported new small molecules incorporating heterocyclic rings, imidazolidinedione, and pyrrolidinedione showing excellent antitumor activity.…”