Synthesis and preliminary evaluation of a PET-FI bimodal imaging agent targeting estrogen receptor

Cheng, Xuebo; Yang, Zhaoguang; Sun, Yi; Zheng, Wei; Chen, Hualong; Liu, Yajing; Wu, Zehui

doi:10.1016/j.bmcl.2021.127776

Cited by 2 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This strategy may be recommended in bimodal PET/ fluorescence imaging. A similar situation would be expected for 124 I due to the ease of electrophilic radiolabeling of proteins but is probably hampered by the limited supply in this isotope.…”

Section: Dual Imaging Dye Approachmentioning

confidence: 52%

“…• a bis-functionalized metal chelator 70,96,98,118,124 • a bis-functionalized fluorophore 68,110,112 • a bifunctional connector like amino acids 64,87 Among the different approaches, this is the most versatile. The fact that the dual imaging dye is conjugated to the vector in a single last step in the construction of the imaging tool allows for the preparation of a wide array of agents by simply changing the vectors, without rebuilding the whole edifice.…”

Section: Dualmentioning

confidence: 99%

“…According to this approach, the synthesis of the dual imaging dye relies on reactions between bifunctional entities that can be a bis-functionalized metal chelator ,,,, a bis-functionalized fluorophore ,, a bifunctional connector like amino acids , …”

Section: Dual Pet/fluorescence Imaging Tools: Variety Of Examplesmentioning

confidence: 99%

“…To the exception of 68 Ga, which is routinely produced with a 68 Ge/ 68 Ga generator today, all others are produced in biomedical cyclotrons according to (p,n) nuclear reactions starting from stable 18 O, 64 Ni, 89 Y, and 124 Te for 18 F, 64 Cu, 89 Zr, and 124 I, respectively, and (p,α) from stable 14 N for 11 C. 6−8 This large array of isotopes offers many options in terms of chemistry and decay to optimize the construction of dual imaging tools and to best match their properties for in vivo bimodal imaging applications.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

PET/Fluorescence Imaging: An Overview of the Chemical Strategies to Build Dual Imaging Tools

et al. 2022

View full text Add to dashboard Cite

Molecular imaging is a biomedical research discipline that has quickly emerged to afford the observation, characterization, monitoring, and quantification of biomarkers and biological processes in living organism. It covers a large array of imaging techniques, each of which provides anatomical, functional, or metabolic information. Multimodality, as the combination of two or more of these techniques, has proven to be one of the best options to boost their individual properties, hence offering unprecedented tools for human health. In this review, we will focus on the combination of positron emission tomography and fluorescence imaging from the specific perspective of the chemical synthesis of dual imaging agents. Based on a detailed analysis of the literature, this review aims at giving a comprehensive overview of the chemical strategies implemented to build adequate imaging tools considering radiohalogens and radiometals as positron emitters, fluorescent dyes mostly emitting in the NIR window and all types of targeting vectors.

show abstract

Section: Dual Imaging Dye Approachmentioning

confidence: 52%