Synthesis and potential use of 1,8-naphthalimide type 1O2 sensor molecules

Abstract

New double (fluorescent and spin) sensor molecules (4 and 7) were synthesized and their responses to ROS in vitro are reported with perspectives of plant physiology use in vivo.Please check this proof carefully. Our staff will not read it in detail after you have returned it.Translation errors between word-processor files and typesetting systems can occur so the whole proof needs to be read. Please pay particular attention to: tabulated material; equations; numerical data; figures and graphics; and references. If you have not already indicated the corresponding author(s) please mark their name(s) with an asterisk. Please e-mail a list of corrections or the PDF with electronic notes attached -do not change the text within the PDF file or send a revised manuscript.Please bear in mind that minor layout improvements, e.g. in line breaking, table widths and graphic placement, are routinely applied to the final version.We will publish articles on the web as soon as possible after receiving your corrections; no late corrections will be made.Please return your final corrections, where possible within 48 hours of receipt, by e-mail to: pps@rsc.org Reprints-Electronic (PDF) reprints will be provided free of charge to the corresponding author. Enquiries about purchasing paper reprints should be addressed via: http://www.rsc.org/publishing/journals/guidelines/paperreprints/. Costs for reprints are below: Please check the proofs of your paper carefully, paying particular attention to the numerical data, tables, figures and references.When answering the queries below please ensure that any changes required are clearly marked on the proof. There is no need to e-mail your answers to the queries separately from the rest of your proof corrections.

1O2 Generating Luminescent Lanthanide Complexes with 1,8-Naphthalimide-Based Sensitizers

“…Selected derivatives are reported to bind and disable topoisomerase II (the enzyme responsible for DNA packaging) or tubulin, or nitroreductase, considerably hindering cell function. Naphthalimide derivatives are often used as fluorescent reporters. ,,,, Hideg and co-workers described an example used to infiltrate chlorophyll-containing mesophyll cells of tobacco leaves and to detect 1 O 2 in vitro by luminescence in the range 500–600 nm …”

“…17,24,26,36,37 Hideg and co-workers described an example used to infiltrate chlorophyll-containing mesophyll cells of tobacco leaves and to detect 1 O 2 in vitro by luminescence in the range 500−600 nm. 38 1,8-Naphthalimide is easily functionalized, 39 and many groups have investigated ways to increase its potency by adding heavy atoms, 40,41 extending conjugation, 18 or incorporating multiple cytotoxic motifs. 42 Some of these methods do increase the efficiency of ISC, but can result in shortening the lifetime of the 1 S excited states.…”

Photopolymer resins for luminescent three‐dimensional printing

“…To answer this question, we turned to the chemical structure of Solvent Yellow 98. As can be seen in Scheme , Solvent Yellow 98 containing the naphthalimide subunit, which has been demonstrated to be an efficient free radical capturing and quenching moiety . Therefore, although Solvent Yellow 98 has negligible overlap with the photoinitiator, its capability to capture free radical that generated by photoinitiator greatly reduces the curing efficiency.…”

Reactive oxygen species: Reactions and detection from photosynthetic tissues

“…The place where the sensor compound localizes can also affect the results. More 1 O 2 probes exist than are used in plant research and also new probes are being synthesized but the usability of the new probes in photosynthetic systems should be tested before extensive use [117,152,153]. For example, the 1 O 2 probe MVP (trans-1-(2'-methoxyvinyl)pyrene) has long been used e.g.…”