Synthesis and physicochemical properties of dual-responsive acrylic acid/butyl acrylate cross-linked nanogel systems

Ashrafizadeh, Marjan; Tam, Kam Chiu; Javadi, Aliyar; Abdollahi, Mahdi; Sadeghnejad, Saeid; Bahramian, Alireza

doi:10.1016/j.jcis.2019.08.066

Cited by 39 publications

(19 citation statements)

References 67 publications

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“…Meanwhile, the reversible connections of physically crosslinked nanogels are commonly dependent on the noncovalent interactions, which mainly include hydrogen bonding, Van der Waals force, hydrophobic interaction, host-guest interaction, electrostatic interaction, and so on [9]. Although the interaction of physical noncovalent bonds is relatively weaker than that of chemical covalent crosslinking, the process of physical self-assembly is more flexible and convenient, because it does not require complex reactions [10,11]. This section discusses the synthetic methods and examples of nanogel preparation are discussed.…”

Section: Construction Of Nanogelsmentioning

confidence: 99%

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

et al. 2020

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Nanogel-based nanoplatforms have become a tremendously promising system of drug delivery. Nanogels constructed by chemical crosslinking or physical self-assembly exhibit the ability to encapsulate hydrophilic or hydrophobic therapeutics, including but not limited to small-molecule compounds and proteins, DNA/RNA sequences, and even ultrasmall nanoparticles, within their 3D polymer network. The nanosized nature of the carriers endows them with a specific surface area and inner space, increasing the stability of loaded drugs and prolonging their circulation time. Reactions or the cleavage of chemical bonds in the structure of drug-loaded nanogels have been shown to trigger the controlled or sustained drug release. Through the design of specific chemical structures and different methods of production, nanogels can realize diverse responsiveness (temperature-sensitive, pH-sensitive and redox-sensitive), and enable the stimuli-responsive release of drugs in the microenvironments of various diseases. To improve therapeutic outcomes and increase the precision of therapy, nanogels can be modified by specific ligands to achieve active targeting and enhance the drug accumulation in disease sites. Moreover, the biomembrane-camouflaged nanogels exhibit additional intelligent targeted delivery features. Consequently, the targeted delivery of therapeutic agents, as well as the combinational therapy strategy, result in the improved efficacy of disease treatments, though the introduction of a multifunctional nanogel-based drug delivery system.

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Section: Construction Of Nanogelsmentioning

confidence: 99%

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

et al. 2020

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“…The crosslinked polymer network was generated via the intermolecular disulfide exchange reaction in the aqueous phase. Otherwise, the organic phase could be composed by the monomers: Ashrafizadeh et al [29] proposed the design of amphiphilic pH-responsive NGs using a mixture of acrylate monomers and a dimethacrylate cross-linker combined with an aqueous solution of initiatior to activate the emulsion polymerization. Furthermore, another innovative approach has been discussed by Wang and collaborators [30], who have prepared NGs by emulsion-free photopolymerization: they combined the self-emulsification of poly(ethylene glycol) diacrylate monomer and the small irradiation region of a low-cost semiconductor laser to achieve a spatiotemporally controllable photopolymerization.…”

Section: Emulsion Polymerizationmentioning

confidence: 99%

Synthesis of Nanogels: Current Trends and Future Outlook

Mauri

Giannitelli

Trombetta

et al. 2021

Gels

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Nanogels represent an innovative platform for tunable drug release and targeted therapy in several biomedical applications, ranging from cancer to neurological disorders. The design of these nanocarriers is a pivotal topic investigated by the researchers over the years, with the aim to optimize the procedures and provide advanced nanomaterials. Chemical reactions, physical interactions and the developments of engineered devices are the three main areas explored to overcome the shortcomings of the traditional nanofabrication approaches. This review proposes a focus on the current techniques used in nanogel design, highlighting the upgrades in physico-chemical methodologies, microfluidics and 3D printing. Polymers and biomolecules can be combined to produce ad hoc nanonetworks according to the final curative aims, preserving the criteria of biocompatibility and biodegradability. Controlled polymerization, interfacial reactions, sol-gel transition, manipulation of the fluids at the nanoscale, lab-on-a-chip technology and 3D printing are the leading strategies to lean on in the next future and offer new solutions to the critical healthcare scenarios.

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“…Nanogels have been widely used as drug carriers partly because of their capacity of being loaded with agents having different properties (Table 1) (Vinogradov et al, 2002;Morimoto et al, 2006;Oh et al, 2007;Oh et al, 2008;Ashrafizadeh et al, 2019). When nanogels are developed for drug delivery purposes, monomers are selected according to the mechanism of action of the drug to be delivered (Vinogradov, 2007;Bae et al, 2008).…”

Section: Applications In Drug Deliverymentioning

confidence: 99%

Preparation and use of nanogels as carriers of drugs

Obireddy

Lai

2021

Drug Delivery

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Nanogels have high tunability and stability while being able to sense and respond to external stimuli by showing changes in the gel volume, water content, colloidal stability, mechanical strength, and other physical/chemical properties. In this article, advances in the preparation of nanogels will be reviewed. The application potential of nanogels in drug delivery will also be highlighted. It is the objective of this article to present a snapshot of the recent knowledge of nanogel preparation and application for future research in drug delivery.

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Synthesis and physicochemical properties of dual-responsive acrylic acid/butyl acrylate cross-linked nanogel systems

Cited by 39 publications

References 67 publications

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

Synthesis of Nanogels: Current Trends and Future Outlook

Preparation and use of nanogels as carriers of drugs

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