Synthesis and Physicochemical Characterization of Biodegradable PLGA-based Magnetic Nanoparticles Containing Amoxicilin

Abstract

The purposes of this research were to synthesize amoxicillin-carrying magnetic nanoparticles. Magnetic nanoparticles were prepared by a chemical precipitation of ferric and ferrous chloride salts in the presence of a strong basic solution. PLGA and PLGA-PEG copolymers were prepared by ring opening polymerization of lactide (LA) and glycolide (GA) (mole ratio of LA: GA 3:1) with or without polyethylene glycol (PEG). Amoxicillin loaded magnetic PLGA and PLGA-PEG nanoparticles were prepared by an emulsion-evaporation process (o/w). Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) photomicrographs showed that the magnetic nanoparticles have the mean diameter within the range of 65-260 nm also they were almost spherical in shape. Magnetic nanoparticles prepared with PLGA showed more efficient entrapment (90%) as compared with PLGA-PEG (48-52%) nanoparticles. In-vitro release of amoxicillin from magnetic PLGA nanoparticles showed that 78% of drug was released over 24 hours. The amount of amoxicillin released from PLGA-PEG s was higher than PLGA.

Depot injectable atorvastatin biodegradable in situ gel: development, optimization, in vitro, and in vivo evaluation

“…This was obvious in the amidic group, C–OH-stretching alcoholic group, and C–H-stretching. Incorporation of PEG causes slight decrease in the glass transition temperature value of PLGA from 48°C to about 45.5°C as previously illustrated by Alimohammadi et al 34 Also, the plasticizing effect of PEG previously mentioned is based on the reduction of the attractive forces among the polymer chains. These effects could explain the decrease in the drug burst effect after incorporation of PEG in the formulation.…”

“…The plasticizing effect of PEG could be attributed to the decrease in the glass transition temperature of PLGA from 48°C to about 45.5°C for both PLGA–PEG 2000 and PLGA–PEG 4000 derivatives. 34 …”

Preparation of Parenteral in situ Gel Formulation Based on smart PLGA polymer: Concepts to Decrease Initial Drug Burst and extend drug release

“…They concluded that the burst effect was influenced by the solvent mixture (NMP and PEG 400). Incorporation of PEG causes a slight decrease in the glass transition temperature of PLGA from 48 °C to about 45.5 °C as previously illustrated by Alimohammadi et al [48]. The plasticizing effect of PEG is based on the reduction of the attractive forces among the polymer chains.…”

<i>In Vitro</i> Studies of NIPAAM-MAA-VP Copolymer-Coated Magnetic Nanoparticles for Controlled Anticancer Drug Release*

“…These nanoparicales are better to the traditional stimuli-responsive systems such as pH and temperature-sensitive polymers, because they offer the benefit of noncontact force (e.g., an external magnetic field) [4,5]. The external magnetic field is used to guide nanoparticales to a disease site and persuade heat as a motivation to the polymer shell [5,6]. These magnetic targeted carriers have also been designed with dual functionality as imaging agents and drug carriers [7].…”