Synthesis and Photophysical Properties of a Series of Novel Porphyrin Dendrimers Containing Organoiron Complexes

Alsehli, Mosa; Al‐Raqa, Shaya Y.; Kucukkaya, Inan; Shipley, Paul R.; Wagner, Brian D.; Abd‐El‐Aziz, Alaa S.

doi:10.1007/s10904-018-1019-0

Cited by 7 publications

(3 citation statements)

References 36 publications

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“…Due to their unique chemical properties, dendrimers are emerging as very important materials and are actively research in recent years. Their globular topology and tailored peripheral end groups enable their use in several applications like, pharmaceutical drug and gene delivery, chemotherapy, and diagnostic imaging [1][2][3][4]. While most dendrimers are organic macromolecules, great efforts are being made to incorporate inorganic main group elements, transition metals, and organometallic entities to create inorganic and organometallic dendrimers.…”

Section: Introductionmentioning

confidence: 99%

Thermodynamic Parameters of Nonisothermal Degradation of A New Family of Organometallic Dendrimer with Isoconversional Methods

Joraid

Okasha

Al‐Maghrabi³

et al. 2021

Preprint

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The objective of this work is to obtain the thermodynamic parameters, namely, the changes of enthalpy, Gibbs free energy, and the entropy of two degradation steps observed in three of a new family of organometallic dendrimers. The isoconversional Flynn-Wall-Ozawa (FWO) model was employed to calculate the effective activation energy and pre-exponential factor. The changes of enthalpy and the entropy was consistent with the activation energy, whereas the change of Gibbs free energy remains positive during the entire degradation process, implying that the degradation is non-spontaneous and thus requires external heat supply.

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Section: Introductionmentioning

confidence: 99%

Thermodynamic Parameters of Nonisothermal Degradation of A New Family of Organometallic Dendrimer with Isoconversional Methods

Joraid

Okasha

Al‐Maghrabi³

et al. 2021

Preprint

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“…Dendrimers are unique highly branched 3-dimensional macromolecules that arise from a central core [ 7 , 8 , 9 , 10 ]. Several unique properties associated with dendrimers allows them to be used in many applications such as catalysis [ 11 , 12 , 13 , 14 ], sensing [ 15 , 16 , 17 ], and fluorescence applications [ 18 , 19 , 20 , 21 , 22 ], General synthesis routes to these dendrimers involve functionalizing the periphery with antimicrobial agents [ 6 ]. The search for unique synthesis approaches of antimicrobial dendrimers is expanding with the focus on enhanced activity upon resistant strains [ 15 , 16 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Design of Organoiron Dendrimers Containing Paracetamol for Enhanced Antibacterial Efficacy

2020

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Paracetamol (acetaminophen) is a common painkiller and antipyretic drug used globally. Attachment of paracetamol to a series of organoiron dendrimers was successfully synthesized. The aim of this study is to combine the benefits of the presence of these redox-active organoiron dendrimers, their antimicrobial activities against some human pathogenic Gram-positive, and the therapeutic characteristics of paracetamol. The antimicrobial activity of these dendrimers was investigated and tested with a minimum inhibitory concentration and this has been reported. Some of these newly synthesized dendrimers exhibited the highest inhibitory activity against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecium (VRE), and Staphylococcus warneri compared to reference drugs. The results of this study indicate that the antimicrobial efficacy of the dendrimers is dependent on the size of the redox-active organoiron dendrimer and its terminal functionalities. The best result has been recorded for the fourth-generation dendrimer 11, which attached to 48 paracetamol end groups and has 90 units composed of the η6-aryl-η5-cyclopentadienyliron (II) complex. This dendrimer presented inhibition of 50% of the growth (IC50) of 0.52 μM for MRSA, 1.02 μM for VRE, and 0.73 μM for Staphylococcus warneri. The structures of the dendrimers were characterized by elemental analysis, Fourier transform infrared (FT-IR), nuclear magnetic resonance (1H-NMR), and 13C-NMR spectroscopic techniques. In addition, all synthesized dendrimers displayed good thermal stability in the range of 300–350 °C following the degradation of the cationic iron moieties which occurred around 200 °C.

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“…Utilization of dendrimers as a host for different molecules, such as drugs, and investigation of the role of hydrogen bonding in these drug delivery systems were started in 1995 [11,12]. With ahighly symmetric structure, dendrimers have well-defined nanostructure [13]. In fact, dendrimers describe a family of synthetic polymers that are highly branched three-dimensional structures in nature.…”

Section: Introductionmentioning

confidence: 99%

Nanostructures of PAMAM Dendrimers in Drug Delivery System for 5-Fluorouracil

Haghighi

Morsali

Bozorgmehr

et al. 2020

Journal of Siberian Federal University. Chemistry

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In this article, we studied five noncovalent structures for adsorption of 5 fluorouracil drug (5 FL) on poly(amidoamine) G0 generation dendrimer (PAMAMG0) carrier using M06-2X and B3LYPfunctionals. We investigate the quantum molecular descriptors and the binding and solvation energies in gas phase and aqueous solution. The energetic stability of non-bonded species (PAMAMG0/5-FL1-5) was shown through evaluation of binding free energies. The solvation free energies of PAMAMG0/5-FL1-5 are negative, indicating that the solvation process is spontaneous. We considered quantum molecular descriptors such as electrophilicity power and global hardness and found reduced toxicity of 5-FL drug near PAMAMG0 carrier as well as facilitated drug release. The AIM (Atoms In Molecule) analysis for all PAMAMG0/5-FL1-5 structures demonstrated that the pseudo-hydrogen and hydrogen bonds are essential in the functionalization of PAMAMG0 with 5-FL drug. We found thatthe structure in which 5-FL drug interacts with CO functional groups of PAMAMG0 is the most stable configuration

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Synthesis and Photophysical Properties of a Series of Novel Porphyrin Dendrimers Containing Organoiron Complexes

Cited by 7 publications

References 36 publications

Thermodynamic Parameters of Nonisothermal Degradation of A New Family of Organometallic Dendrimer with Isoconversional Methods

Thermodynamic Parameters of Nonisothermal Degradation of A New Family of Organometallic Dendrimer with Isoconversional Methods

Design of Organoiron Dendrimers Containing Paracetamol for Enhanced Antibacterial Efficacy

Nanostructures of PAMAM Dendrimers in Drug Delivery System for 5-Fluorouracil

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