Synthesis and photochemical properties of caged peroxides for photocontrol of cellular oxidative stress

Tsuji, Mieko; Taira, Hirofumi; Udagawa, Taro; Aoki, Tatsuya; Hirayama, Tasuku; Nagasawa, Hideko

doi:10.1039/d3cc01192e

Chem. Commun.

2023

DOI: 10.1039/d3cc01192e

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Synthesis and photochemical properties of caged peroxides for photocontrol of cellular oxidative stress

Mieko Tsuji

Hirofumi Taira

Taro Udagawa

et al.

Abstract: We developed a caged hydroperoxide, BhcTBHP, releasing prooxidant TBHP under blue light irradiation. MitoTBHP with triphenylphosphonium at the position 7 triggered selective oxidative stress and membrane depolarization in mitochondria upon...

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2024

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References 30 publications

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Design and synthesis of visible light-activatable photocaged peroxides for optical control of ROS-mediated cellular signaling

Tsuji,

Koiso,

Nishimura

et al. 2024

Bioorganic & Medicinal Chemistry

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Design and synthesis of visible light-activatable photocaged peroxides for optical control of ROS-mediated cellular signaling

Tsuji,

Koiso,

Nishimura

et al. 2024

Bioorganic & Medicinal Chemistry

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Synthesis and photochemical properties of caged peroxides for photocontrol of cellular oxidative stress

Abstract: We developed a caged hydroperoxide, BhcTBHP, releasing prooxidant TBHP under blue light irradiation. MitoTBHP with triphenylphosphonium at the position 7 triggered selective oxidative stress and membrane depolarization in mitochondria upon...

Cited by 1 publication

References 30 publications

Design and synthesis of visible light-activatable photocaged peroxides for optical control of ROS-mediated cellular signaling

Design and synthesis of visible light-activatable photocaged peroxides for optical control of ROS-mediated cellular signaling

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