“…Our interest in solid-phase synthesis, support modification, and cross-link functionalization prompted us to investigate the properties of oligo(ethylene glycol) cross-linked PS beads. Poly(ethylene glycol) [PEG], introduced via grafting to chloromethylated PS−DVB, has been shown to increase swelling in polar solvents, and several PEG-grafted PS−DVB supports have emerged (cf., TentaGel and ArgoGel) based on the work of Inman, Regen, Mutter, Bayer and Rapp, Barany, and others . A drawback of the grafting approach, however, is that it reduces the functional group-to-mass ratio (polymer loading) by decreasing the number of free chloromethyl groups while increasing the resin mass.…”