Synthesis and pharmacology of some N-substituted derivatives of 1-amino-4,6-dimethylbenzocyclobutene

In Vitro Effect of Some Chemicals on Histaminopexy II: Quantification and Potentiation of Histaminopexy

“…The perceptual or sensory alterations caused by drugs enable animals to learn differential responses solely on the basis of whether they are in a drug or nondrug condition (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). Such learning may provide part of the explanation for the development of abnormal patterns of behavior under the influence of alcohol or other drugs (11).…”

“…A technique for training animals to perform differential responses on the basis of their drug or nondrug condition may be used for investigating various problems of pharmacological interest. Problems which have been investigated include tests of similarities or dissimilarities in the perceptual or sensory effects of different compounds (2,5), measurements of the threshold dose below which the animal cannot differentiate the drug from the nondrug condition (3, 5), and attempts to identify the central or peripheral alteration which is the basis for the differential responses in the drug and nondrug conditions (3, 5, 10).…”

“…This observation (2), coupled with the finding that quercetin was capable of enhancing the binding of histamine by serum proteins, suggested further study of this interaction which could possibly be the basis of a novel alleviation of symptoms of histamine-related allergies. EXPERIMENTAL A modified dialysis procedure (2) was employed in which a mixture of gamma globulin and an equal volume of aqueous radioactive histamine dihydrochloride was equilibrated against Tyrode's solution. Cellulose dialysis tubing' of approximately 25-cm.…”