Synthesis and pharmacological properties of α-homoanalogs of 11-desoxyprostaglandin E1

Structure-biological activity relationship in prostaglandin analogs

“…The response was recorded with a Model T2 4620 Line Recorder using a spe-cial chart paper [24,25]. The activity was evaluated using changes in the amplitude, tone, and frequency of sample tissue oscillations.…”

“…The activity was evaluated using changes in the amplitude, tone, and frequency of sample tissue oscillations. The antiulcer activity was studied during a fall -winter period on a group of 40 matured white male Wistar line rats and 50 white mongrel mice with a model of acute experimental ulcer of the gastric mucous membrane caused by acetylsalicylic acid (double treatment via gastric tube in a total dose of 300 mg/kg with a 4-h interval) and indomethacin (single intraperitoneal injection in a dose of 20 mg/kg) [25,26]. The animals were deprived of meals and water on day before test.…”