Synthesis and pharmacological activity of 3-(2,2,2-trichloro-1-hydroxyethyl)imidazo [1, 2-a]benzimidazole dihydrochlorides

Anisimova, V. A.; Spasov, A. A.; Косолапов, В. А.; Толпыгин, И. Е.; Porotikov, V. I.; Kucheryavenko, A. F.; Sysoeva, V. A.; Тибирькова, Е. В.

doi:10.1007/s11094-009-0340-x

Cited by 15 publications

(10 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Amides of 2,3-dihydroimidazo-and 2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazolyl-acetic acids showed moderate AO activity compared to dibunol [18]. It was revealed that 2-methoxy-phenyl-and 2-oxyphenyl-substituted 1-dialkylaminoalkyl-IMBI [8], N-acylmethyl derivatives of 9H-2,3-dihydro-IMBI and 10H-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoles [9], most of 3-(2,2,2-trichloro-1-hydroxyethyl)-IMBI [12] и 3-acetyl-2-R-9-dialkylaminoethyl-IMBI [13], 1-dialkyl(alkyl)aminoethyl-2,3-dihydro-IMBI [14], and 3-(n,n-disubstituted)acetamide-1-r-2-aminobenzimidazolium [17] showed the weak antioxidant activity compared to the reference drug. Among 10-alkylaminoethyl-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoles [16] and phenyl-and alkylthiocarbamides of 2,9-disubstituted IMBI [19], antioxidant action has not been found.…”

Section: The Resultsmentioning

confidence: 99%

Condensed Benzimidazoles Are a Novel Scaffold for Antioxidant Agents’ Search and Development

Косолапов¹,

Спасов²,

Анисимова³

et al. 2019

Antioxidants

View full text Add to dashboard Cite

Taking into account that the imidazole ring has π-electron redundancy, condensed benzimidazole derivatives have attracted our attention as a promising class for the search for antioxidant substances. Synthesis was carried out, and information on the antioxidant activity of imidazo-and tetrahydropyrimido benzimidazoles was provided. Highly active antioxidant substance enoxifol has been revealed. The data on the synthesis and study of the pharmacodynamic, pharmacokinetic, and toxicological properties of the new antioxidant compound enoxifol are presented. The antioxidant activity of the compound is due to its ability to inactivate superoxide, hydroxyl, and peroxyl radicals, thereby reducing the overall oxidation rate due to a decrease in the total initiation rate. It has been shown that enoxifol has hepatoprotector, antihypoxic, cerebroprotective, nootropic, stressprotective, neuropsychotropic, actoprotective, cardioprotective, antiaggregant, and antithrombogenic properties and is able to prevent rheological disorders in diabetes mellitus.

show abstract

Section: The Resultsmentioning

confidence: 99%

Condensed Benzimidazoles Are a Novel Scaffold for Antioxidant Agents’ Search and Development

Косолапов¹,

Спасов²,

Анисимова³

et al. 2019

Antioxidants

View full text Add to dashboard Cite

show abstract

“…The object of this study is to investigate the inhibition properties of a group of some newly synthesised diazoles that acts as corrosion inhibitor for steel in acidic media [27][28][29][30] and easy to produce with purities greater than 99%. All of the compounds investigated are reported here for the first time.…”

Section: Introductionmentioning

confidence: 99%

Effect of some new diazole derivatives on the corrosion behaviour of steel in 1 M HCl

Abboud

Ihssane

Hammouti

et al. 2010

Desalination and Water Treatment

View full text Add to dashboard Cite

ab s t r ac tThe inhibiting properties of four diazole derivatives namely 2,2'-ethylene-bis(benzimidazole) (EBBI), 2,2'-buthylene-bis(benzimidazole) (BBBI), 2,2'-hexamethylene-bis(benzimidazole) (HBBI) and 2,2'-octamethylene-bis(benzimidazole) (OBBI), against the corrosion of mild steel in solutions of hydrochloric acid has been studied by various corrosion monitoring techniques and reported here for the first time. Preliminary screening of the inhibition efficiency was carried out using weight loss measurements. At the inhibitor concentration range of 10 -5 -5×10 -4 M) in 1 M HCl, the inhibitor efficiency increases with concentration of the organic substrate. Potentiodynamic polarisation studies showed that these compounds suppressed both cathodic and anodic processes of mild steel corrosion in 1 M HCl by adsorption on the metal surface according to Langmuir adsorption isotherm. The values of free energies of adsorption (ΔG 0 ads ) suggest a mixed physisorptions and chemisorption of diazole molecules on the steel surface. The inhibition efficiency of these inhibitors increases in the order OBBI > HBBI > BBI > EBBI.

show abstract

“…It is known that many diseases reduce its antithrombotic potential. In addition, side effects of the known antiplatelet agent acetylsalicylic acid are associated with prostacyclin production suppression by the vascular wall [12].Previous studies have shown the ability of substituted heterocyclic nitrogen-containing compounds to inhibit platelet aggregation [1,7,9]. Among the new indole derivatives, compound Sbt-828 exhibited high antithrombogenic activity in vitro and in vivo [8], so it seemed interesting to find out whether the antiplatelet action of this compound is related to the influence on the prostacyclin-thromboxane balance.…”

mentioning

confidence: 99%

“…Previous studies have shown the ability of substituted heterocyclic nitrogen-containing compounds to inhibit platelet aggregation [1,7,9]. Among the new indole derivatives, compound Sbt-828 exhibited high antithrombogenic activity in vitro and in vivo [8], so it seemed interesting to find out whether the antiplatelet action of this compound is related to the influence on the prostacyclin-thromboxane balance.…”

mentioning

confidence: 99%

Effect of Compound Sbt-828, a New Indole Derivative Exhibiting Antiaggregant Activity, on the Prostacyclin—Thromboxane A2 Balance

et al. 2017

Self Cite

View full text Add to dashboard Cite

We investigated the effect of a new indole derivative Sbt-828 with antiaggregant properties on prostacyclin-generating activity of the vascular wall and thromboxane A level in platelets of intact rats. The substance under study did not affect prostacyclin production by the vascular wall and significantly reduced thromboxane A level, being superior to the reference drug acetylsalicylic acid by 1.6 times, as seen from reduced malonic dialdehyde level in the thrombin-induced rat platelets.

show abstract

Synthesis and pharmacological activity of 3-(2,2,2-trichloro-1-hydroxyethyl)imidazo [1, 2-a]benzimidazole dihydrochlorides

Cited by 15 publications

References 8 publications

Condensed Benzimidazoles Are a Novel Scaffold for Antioxidant Agents’ Search and Development

Condensed Benzimidazoles Are a Novel Scaffold for Antioxidant Agents’ Search and Development

Effect of some new diazole derivatives on the corrosion behaviour of steel in 1 M HCl

Effect of Compound Sbt-828, a New Indole Derivative Exhibiting Antiaggregant Activity, on the Prostacyclin—Thromboxane A2 Balance

Contact Info

Product

Resources

About