Synthesis and pharmacological activity of 2-oxo-(2H) 1-benzopyran-3-carboxamide derivatives

Crystal structure of 2-amino-4-(3,4-difluorophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile, C16H12N2O2F2

“…Di erent substituents at the aromatic ring lead to multiple chemical modi cations which generates antioxidant, anti-in ammatory, antibacterial and anticancer activities for these compounds [1,2]. Recognizing the considerable importance of the compounds, research focused on the synthesis of dihydropyran derivatives [3,4]. In the crystal structure of the title compound, the pyran ring and the adjacent cyclohexenone ring are both basically planar, and the two planes are also essentially parallel each other.…”

Crystal structure of 2-amino-4-(2,6-dichlorophenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile, C18H16Cl2N2O2

“…Dihydropyran and its derivatives have received considerable attention in the past few years for their versatile biological and medical activities because of di erent substituents on the aromatic ring leading to multiple chemical modi cations, such as antioxidant, anti-in ammatory, antibacterial and anticancer activities [1][2][3]. Recognizing the considerable importance of the compounds, research focused on the synthesis of dihydropyran derivatives [4].…”

Crystal structure of 2-amino-4-(4-fluorophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile, C16H13FN2O2

“…Dihydropyran derivatives are one of the most commonly encountered heterocycles, which forms the important component of pharmacophores for a number of compounds having medicinal signi cance including anticancer, antiviral, antibacterial, antioxidant, anti-HIV, antihyperglycemic and anti-dyslipidemic activities [2][3][4]. Recognizing the considerable importance of the compounds, research focused on the synthesis of dihydropyran derivatives [5].…”