Synthesis and pharmacological activity of N-hetaryl-3(5)-nitropyridines

Abstract

Reacting a number chlorosubstituted 3(5)-nitropyridine with some diazoles or 3-chloropyridazin-6-one synthesized previously undescribed various 2-, 4- or 6-substituted hetaryl-3(5)-nitropyridines. Furthermore, pyrazolyl-3-nitropyridine prepared by cyclizing hydrazinopyridine resulting from the nucleophilic substitution of chlorine in chlorosubstituted 3-nitropyridine by hydrazine. It has been shown that these compounds have moderate antibacterial activity against some pathogenic Gram-positive and Gram-negative bacteria (Staphylococcus aureus, Escherichia coli), as well as a strong effect on protistocidal action form Colpoda steinii, surpassing clinically used reference drugs.

Synthesis, characterization, biological evaluation and molecular docking studies of 2-(1H-benzo[d]imidazol-2-ylthio)-N-(substituted 4-oxothiazolidin-3-yl) acetamides

“…Antibiotics are one of the significant therapeutic discoveries of the 20th century in combating the battle against life-threatening microbial infections [ 1 ]. However, multi-drug resistant infections are of particular concern as it causes an annual toll of about 25,000 patients, even in the European countries [ 2 ]. Over the past few decades, the problems posed by multi-drug resistant microorganisms have reached an alarming level leading to a serious challenge to the medical community [ 3 ].…”