Synthesis and Pharmacological Activities of 2-(3'-substituted-2'-hydroxypropylamino)pyridines.

Synthesis, Anticonvulsant and Antihypertensive Activities of 8-Substituted Quinoline Derivatives

“…The increase in the carbon atom number at the 4th position of piperazine influenced the activity remarkably. In the propanol series (12)(13)(14)(15)(16)(17)(18)(19)(20), only compounds 13, 14, 19 and 20 were found to have a high degree of protection against MES-induced convulsions. 4-phenylpiperazino substituted compounds at the 3Ј position showed higher protection than the other substitutions at piperazine compounds.…”

“…We have already reported the potential anticonvulsant activity and the b-blocking activity of propanolamine, aminopropane and aminoethane from our laboratory. [14][15][16][17][18][19][20] To explore the heteroaryl and propanolamine/aminoethane combination, it was envisaged that chemical entities with both quinoline and aryloxypropanolamine/aminoethane moieties would result in compounds with interesting biological activities.…”

Synthesis and anticancer activity of novel 2-substituted pyranopyridine derivatives

“…It constitutes the basic core in many products such as drugs, vitamins and food. Literature survey indicates that a large number of pyridine derivatives are associated with diverse pharmacological properties, such as antimicrobial [1][2][3], antiviral [4], antifungal and antimycobacterial [5], anticancer [6], sodium channel modulation [7][8][9][10][11][12] and anticonvulsant [13] activities. Also, the naturally occurring B6-vitamins pyridoxine, pyrodoxal, pyridoxamine and codecarboxylase contain a pyridine nucleus [14].…”

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A novel series of 2-aminopyranopyridine derivatives (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) were synthesized utilizing 2-chloro-4-(thiophen-2-yl)-7,8-dihydro-5H-pyrano[4,3-b]pyridine-3-carbonitrile (2) as a key starting compound. The structures of the newly synthesized compounds were confirmed on the basis of elemental analyses and infrared (IR), 1 H, 13 C-nuclear magnetic resonance (NMR) and mass spectra.

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Synthesis and Anticonvulsant Activity of Novel 1-Substituted-1,2-dihydro-pyridazine-3,6-diones

“…In view of these new biodynamic agents from heterocyclic compounds, it was thought worthwhile to study the effects of two pharmacophoric moieties like pyridazine and propanolamine/aminopropane in a single molecule, on the biological activity. We have reported the potential anticonvulsant activity of substituted aminopropanes and propanol amines from our lab [16][17][18][19][20][21] to continue our work in the same direction, it was envisaged that the chemical entities with pyridazine, and propanolamine/aminopropane moieties would result in compounds of interesting biological activities.…”