Synthesis and optimization of novel allylated mono-carbonyl analogs of curcumin (MACs) act as potent anti-inflammatory agents against LPS-induced acute lung injury (ALI) in rats

Zhu, Heping; Xu, Tingting; Qiu, Chenyu; Wu, Beibei; Zhang, Yali; Chen, Lingfeng; Xia, Qinqin; Li, Chenglong; Zhou, Bin; Liu, Zhiguo; Liang, Guang

doi:10.1016/j.ejmech.2016.05.041

Cited by 53 publications

(22 citation statements)

References 23 publications

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“…As numerous articles reported, curcumin promoted the degradation of TNF-α and IL-6 expressed by LPS stimulation (Zhu et al. 2016 ). And the phosphoinositide 3-kinase (PI3K)-AKT signalling pathway plays a crucial role in the anti-inflammatory effects of curcumin in LPS-activated inflammatory responses (Cianciulli et al.…”

Section: Introductionmentioning

confidence: 98%

Anti-inflammatory effects of curcumin are associated with down regulating microRNA-155 in LPS-treated macrophages and mice

Liu

Ding

et al. 2017

Pharmaceutical Biology

109

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Context: The natural polyphenolic compound curcumin has been proved to modulate innate immune responses and possess anti-inflammatory properties. Nevertheless, the mechanism remains poorly understood, particularly regarding curcumin-regulated miRNAs under inflammatory response.Objective: This study investigates the role of miRNA-155 in the effects of curcumin on inflammatory response in cell and a mouse model.Materials and methods: The anti-inflammatory activity of curcumin (5, 10 and 15 μM, 2 h) in lipopolysaccharide (LPS, 200 ng/mL)-induced cells were measured by quantitative PCR. The animals were treated orally by 20 mg/kg curcumin for 3 days before an LPS intraperitoneal injection (10 mg/kg, 16 h). MicroRNA (miRNA) expression and the underlying molecular mechanisms were assessed using transfection technique and western blotting.Results and discussion: Curcumin efficiently inhibited LPS-induced cytokines (TNF-α, IL-6) and microRNA-155 (miR-155) expression (p < 0.05) without affecting the normally growth of Raw264.7 and THP-1 cells (IC50 21.8 and 22.3 μM at 48 h, respectively). Moreover, the levels of cytokines were suppressed by curcumin in miR-155 mimics transfected cells (p < 0.05). A blockade of PI3K/AKT signalling pathways resulted in a decreased level of miR-155 (p < 0.05). Curcumin effectively protected mice from sepsis as evidenced by decreasing histological damage, reducing AST (352.0 vs 279.3 U/L), BUN (14.8 vs 10.8 mmol/L) levels and the proportion of macrophages in spleen (31.1% vs 13.5%). MicroRNA-155 level and cytokines were also reduced in curcumin-treated mice (p < 0.05).Conclusions: Curcumin’s ability to suppress LPS-induced inflammatory response may be due to the inhibition of miR-155.

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Section: Introductionmentioning

confidence: 98%

Anti-inflammatory effects of curcumin are associated with down regulating microRNA-155 in LPS-treated macrophages and mice

Liu

Ding

et al. 2017

Pharmaceutical Biology

109

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“…Its anti‐tumour effect has been observed in several cultural cells and animal systems through inducing apoptosis by elevating pro‐apoptotic elements including Bax, cytosolic cytochrome C, activated‐caspase‐3, and activated‐caspase‐9, promoting S phase arrest, suppressing NF‐κB signalling and so forth. Meanwhile, curcumin (CUR) as a multi‐target agent in the spice turmeric exhibited anti‐inflammatory, anti‐proliferative, anti‐oxidant, pro‐apoptotic and so forth effects against a variety of cancer models. It also enhanced the efficacy of some chemotherapy drugs by improving their pharmacokinetics, inducing apoptosis and so on.…”

Section: Introductionmentioning

confidence: 99%

Curcumin enhances the anti‐cancer effects of Paris Saponin II in lung cancer cells

et al. 2018

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“…Tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) are well-known pro-inflammatory cytokines that modulate the expression of immune regulatory genes relevant in some critical illnesses including inflammatory related diseases [ 33 ]. RAW macrophages are widely used in the anti-inflammatory assay [ 34 , 35 ].…”

Section: Resultsmentioning

confidence: 99%

Phenolic Acid Profiling, Antioxidant, and Anti-Inflammatory Activities, and miRNA Regulation in the Polyphenols of 16 Blueberry Samples from China

Zhang

Wang

et al. 2017

Molecules

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To investigate the anti-atherosclerosis related mechanism of blueberries, the phenolic acids (PAs) content, antioxidant and anti-inflammatory activities, as well as the microRNA (miRNA) regulation of polyphenol fractions in blueberry samples from China were studied. Sixteen batches of blueberries including 14 commercialized cultivars (Reka, Patriot, Brigitta, Bluecrop, Berkeley, Duke, Darrow, Northland, Northblue, Northcountry, Bluesource, Southgood, O’Neal, and Misty) were used in this study. Seven PAs in the polyphenol fractions from 16 blueberry samples in China were quantified by high performance liquid chromatography/tandem mass spectrometry (HPLC/MS2). The antioxidant activities of blueberry polyphenols were tested by (1,1-diphenyl-2-picrylhydrazyl [DPPH]) assay. The anti-inflammatory (tumor necrosis factor-α [TNF-α] and interleukin-6 [IL-6]) activities of the polyphenol fractions of the blueberries were investigated by using lipopolysaccharide (LPS) induced RAW 264.7 macrophages. The correlation analysis showed that the antioxidant (1,1-diphenyl-2-picrylhydrazyl [DPPH]) and anti-inflammatory (tumor necrosis factor-α [TNF-α] and interleukin-6 [IL-6]) activities of the polyphenol fractions of the blueberries were in accordance with their PA contents. Although the polyphenol-enriched fractions of blueberries could inhibit the microRNAs (miRNAs) (miR-21, miR-146a, and miR-125b) to different extents, no significant contribution from the PAs was observed. The inhibition of these miRNAs could mostly be attributed to the other compounds present in the polyphenol-enriched fraction of the blueberries. This is the first study to evaluate the PAs content, antioxidant and anti-inflammatory activities, and miRNA regulation of Chinese blueberries.

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Synthesis and optimization of novel allylated mono-carbonyl analogs of curcumin (MACs) act as potent anti-inflammatory agents against LPS-induced acute lung injury (ALI) in rats

Cited by 53 publications

References 23 publications

Anti-inflammatory effects of curcumin are associated with down regulating microRNA-155 in LPS-treated macrophages and mice

Anti-inflammatory effects of curcumin are associated with down regulating microRNA-155 in LPS-treated macrophages and mice

Curcumin enhances the anti‐cancer effects of Paris Saponin II in lung cancer cells

Phenolic Acid Profiling, Antioxidant, and Anti-Inflammatory Activities, and miRNA Regulation in the Polyphenols of 16 Blueberry Samples from China

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