Synthesis and optical properties of novel pyrido[1,2-a]benzimidazole-containing 1,3,4-oxadiazole derivatives

Yang, He; Ge, Yanqing; Jia, Jiong; Wang, Jianwu

doi:10.1016/j.jlumin.2010.11.030

Cited by 30 publications

(8 citation statements)

References 26 publications

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“…The structures of all the newly synthesized compounds were confirmed by FTIR, 1 H NMR, 13 Molar ratio of starting materials (1:1:1) and reflux condition a Isolated yield of the pure compound spectroscopic and physiochemical data of compounds 4a-r are given in section 2.…”

Section: Chemistrymentioning

confidence: 99%

“…[9][10][11] Some of them are used as a chemodosimeter for fluoride ions detection 12 and also display interesting photophysical as well as fluorescent properties. 13 On the other hand, indole derivatives have been a topic of substantial research interest in contemporary heterocyclic and medicinal chemistry due to their great significance in the view of their (i) occurrence in nature as a prominent sub-structure of a large number of alkaloids 14 and (ii) wide-ranging biological activities which includes antimicrobial, 15 antitubercular, 16 ghrelin receptor, 17 antioxidant, 18 antiviral 19 and antimalarial. 20 In particular, 3-substituted indole derivatives play a key role in the synthesis of biologically active compounds especially with anticancer, antitumour, hypoglycemic, antiinflammatory, analgesic and antipyretic activities.…”

Section: Introductionmentioning

confidence: 99%

“…The constitution of all the compounds was characterized using elemental analysis, FT-IR, 1 H-NMR, 13 C-NMR and mass spectroscopy. All the compounds were screened for in vitro antimicrobial activity against eight human pathogens, of which three Grampositive bacteria (Streptococcus pneumoniae, Bacillus subtilis, Clostridium tetani), three Gram-negative bacteria (Salmonella typhi, Escherichia coli, Vibrio cholerae) and two fungal pathogens (Candida albicans, Aspergillus fumigatus) using broth microdilution MIC (minimum inhibitory concentration) method according to National Committee for Clinical Laboratory Standards (NCCLS) 24 and ferric reducing antioxidant power (FRAP) was measured by a modified method of Benzie and Strain.…”

Section: Introductionmentioning

confidence: 99%

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An efficient synthesis of 3′-indolyl substituted pyrido[1,2-a]benzimidazoles as potential antimicrobial and antioxidant agents

Kathrotiya

Patel

2013

J Chem Sci

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A new class of indole-based pyrido[1,2-a]benzimidazole derivatives 4a-r have been synthesized by one-pot cyclocondensation reaction of 2-phenyl-1H-indole-3-carboxaldehyde 1a-i, malononitrile 2 and 2cyanomethylbenzimidazole 3a-b in the presence of catalytic amount of NaOH. In vitro antimicrobial activity of the synthesized compounds were investigated against a representative panel of pathogenic strains specifically three Gram-positive bacteria (Streptococcus pneumoniae, Clostridium tetani, Bacillus subtilis), three Gram-negative bacteria (Salmonella typhi, Vibrio cholerae, Escherichia coli) and two fungi (Aspergillus fumigatus, Candida albicans) using broth microdilution MIC (minimum inhibitory concentration) method. In vitro antioxidant activity was evaluated by ferric-reducing antioxidant power (FRAP) assay method. Compounds 4c, 4e, 4l and 4q have been found to be most efficient antimicrobial members while compounds 4h and 4p possess better ferric reducing antioxidant power.

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Section: Chemistrymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An efficient synthesis of 3′-indolyl substituted pyrido[1,2-a]benzimidazoles as potential antimicrobial and antioxidant agents

Kathrotiya

Patel

2013

J Chem Sci

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“…Figure 2 presented the UV spectra of the samples, showing that D002, Cl-D002 and Mg-Cl-D002 had characteristic absorption peaks of benzene ring ranging from 200 to 300 nm, which were attributed to the π-π* transition of conjugate backbone. 27 Compared with D002, the absorption peak of Cl-D002 and Mg-Cl-D002 shifted to 272 nm. This may be caused by the effect of electron withdrawing (Cl) and electron-donating group (Mg) in the -SO 3 H, which impacted on the benzene ring absorption.…”

mentioning

confidence: 94%

LEWIS ACID SITES OF Mg2+-MODIFIED POLYSTYRENE SULFONIC ACID RESIN CATALYSYS FOR SYNTHESIS OF DIBUTYL SUCCINATE

Cheng¹,

Liang²,

Ding³

et al. 2018

Quim. Nova

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The polystyrene sulfonic acid resin catalysts were fabricated, containing elements of Cl and Mg through oxidization and impregnation, and they were characterized by EDS, FT-IR spectra, Py-IR spectra, UV spectra, XPS and TGA to investigate their physiochemical properties. The catalytic performances of these catalysts were examined in the esterification reaction of succinic acid with n-butanol, and the catalytic results showed that modified resins exhibited the highest catalytic activity and achieved a high yield of dibutyl succinate (91.6%) in addition, the modified resin generated new Lewis acid sites and showed significantly higher thermal stability. The experimental results demonstrated that the Mg 2+ coordinated with a sulfonic acid group to form stable active sites, which effectively decreased the deactivation caused by the thermal degradation of sulfonic acid. Moreover, the monomer structures of polystyrene sulfonic acid resin and modified polystyrene sulfonic acid resin have been modelled using B3LYP/6-311G(d,p) approximation.

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“…The design and synthesis of fluorescent small molecules with desirable bioactivities are of considerable current interest in biological research . Thus, in continuation of our efforts at synthesizing various fluorescent small molecules and bioactive molecules , we proposed that imidazo[1,5‐ a ]pyridine linking hydrazone might lead to an improvement in UV–vis absorption and fluorescence spectral characteristics. In addition, they may have interesting bioactivities such as antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, crystal structure, optical properties and antibacterial evaluation of novel imidazo[1, 5‐a]pyridine derivatives bearing a hydrazone moiety

Zhang

et al. 2013

Luminescence

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A series of novel imidazo[1,5-a]pyridine-hydrazone derivatives were synthesized and characterized by infrared spectroscopy (IR), 1H NMR, 13C NMR and high resolution mass spectrometer (HRMS). Typically, the spatial structure of compound 3j was determined using X-ray diffraction analysis. The UV-vis absorption and fluorescence spectral characteristics of the compounds in dichloromethane and acetonitrile were investigated. Absorption peaks could be observed in the wavelength range 290-450 nm. It can also be seen that they display very similar maximum emission. The group attached to hydrazone hardly influenced the maximum emission. Furthermore, all the compounds were evaluated for antibacterial activity and were found to be more effective against Staphylococcus aureus, Listeria monocytogenes, Escherichia coli, Salmonella typhimurium, Pseudomonas aeruginosa and Shigella compared with chloramphenicol.

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Synthesis and optical properties of novel pyrido[1,2-a]benzimidazole-containing 1,3,4-oxadiazole derivatives

Cited by 30 publications

References 26 publications

An efficient synthesis of 3′-indolyl substituted pyrido[1,2-a]benzimidazoles as potential antimicrobial and antioxidant agents

An efficient synthesis of 3′-indolyl substituted pyrido[1,2-a]benzimidazoles as potential antimicrobial and antioxidant agents

LEWIS ACID SITES OF Mg2+-MODIFIED POLYSTYRENE SULFONIC ACID RESIN CATALYSYS FOR SYNTHESIS OF DIBUTYL SUCCINATE

Synthesis, crystal structure, optical properties and antibacterial evaluation of novel imidazo[1, 5‐a]pyridine derivatives bearing a hydrazone moiety

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