Journal of Biomaterials Science, Polymer Edition

1989

DOI: 10.1163/156856289x00109

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Synthesis and non-thrombogenicity of polyurethanes with poly(oxyethylene) side chains in soft segment regions

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Cited by 18 publications

References 29 publications

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Glow discharge plasma deposition of tetraethylene glycol dimethyl ether for fouling‐resistant biomaterial surfaces

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et al. 1992

J. Biomed. Mater. Res.

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The glow discharge plasma deposition (GDPD) of tetraethylene glycol dimethyl ether is introduced as a novel method for obtaining surfaces that are resistant to protein adsorption and cellular attachment. Analysis of films by x-ray photoelectron spectroscopy and several biological assays indicate the formation of a fouling-resistant, PEO-like surface on several substrata (e.g., glass, polytetrafluoroethylene, polyethylene). Adsorption of 125I-radiolabelled proteins (fibrinogen, albumin and IgG) from buffer and plasma was very low (typically less than 20 ng/cm2) when compared to the untreated substrata, which exhibited much higher levels of protein adsorption. Not all coated substrata adsorbed equal amounts of protein (e.g., coated glass samples typically adsorbed more protein than coated polyethylene or coated polytetrafluoroethylene samples), suggesting that the substratum used may affect the amount of protein adsorbed. Measurement of dynamic platelet adhesion, using epifluorescent video microscopy, and endothelial cell attachment further demonstrates the short-term nonadhesiveness of these surfaces.

Glow discharge plasma deposition of tetraethylene glycol dimethyl ether for fouling‐resistant biomaterial surfaces

¹

,

²

,

³

et al. 1992

J. Biomed. Mater. Res.

View full text Add to dashboard Cite

The glow discharge plasma deposition (GDPD) of tetraethylene glycol dimethyl ether is introduced as a novel method for obtaining surfaces that are resistant to protein adsorption and cellular attachment. Analysis of films by x-ray photoelectron spectroscopy and several biological assays indicate the formation of a fouling-resistant, PEO-like surface on several substrata (e.g., glass, polytetrafluoroethylene, polyethylene). Adsorption of 125I-radiolabelled proteins (fibrinogen, albumin and IgG) from buffer and plasma was very low (typically less than 20 ng/cm2) when compared to the untreated substrata, which exhibited much higher levels of protein adsorption. Not all coated substrata adsorbed equal amounts of protein (e.g., coated glass samples typically adsorbed more protein than coated polyethylene or coated polytetrafluoroethylene samples), suggesting that the substratum used may affect the amount of protein adsorbed. Measurement of dynamic platelet adhesion, using epifluorescent video microscopy, and endothelial cell attachment further demonstrates the short-term nonadhesiveness of these surfaces.

Sequential Post-modifications of Polybutadiene for Industrial Applications

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2015

Multi-Component and Sequential Reactions in Polymer Synthesis

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Contemporary topics in polymeric materials for biomedical applications

1996

Advances in Polymer Science

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