Synthesis and neurotropic activity of some γ-aminobutyric acid derivatives

Designing Prodrugs and Bioprecursors

“…32 Typical representatives of such prodrugs are tyrosine methyl ester, 33 levodopa ethyl ester, 34 nipecotic acid ethyl ester, 35 enalaprilat ethyl ester, 36 , 37 trandolapril, 38 γ -aminobutyric acid (GABA) cetyl ester, 39,40 and methotrexate cetyl ester. Simple esters of aliphatic alcohols are attractive, as they are cheap to prepare, chemically stable, and yield harmless hydrolysis products.…”