Synthesis and Molluscicidal Activity of New Chromene and Pyrano[2,3‐c]pyrazole Derivatives

Abstract

The chromene derivative 4 reacts with acetic anhydride, phenylisothiocyanate and ethyl orthoformate to afford the N-acetyl derivative 6, the chromenopyrimidine 8 and the formimidate 9, respectively. 2-(1H-Indol-3-ylmethylene)-malononitrile 10b reacts with 1,3-cyclohexanedione and dimedone 11a, b to afford the 4(3-indolyl)-chromene derivatives 12a, b respectively, and with the pyrazolone derivatives 13a-d to afford the arylidene exchange derivatives 14a-c and the pyranopyrazole derivative 15, respectively. The arylidene derivatives 10a, b react also with indane-1,3-dione 16 to afford the arylidene exchange derivatives 18a, b. The molluscicidal activity of the synthesized compounds towards Biomphalaria alexandrina snails, the intermediate host of Schistosoma mansoni, was investigated and most of them showed weak to moderate activity.

Leucine: green and efficient catalyst for the synthesis of 4H-chromenes

“…Some derivatives of pyrans including chromenes exhibit wide range of biological activities [4], and possess molluscicidal [5], anticancer [6], antitubercular, anticoagulant, antiallergic, antibiotic, hypolipidemic, and immunomodulating properties [7]. These compounds are also industrially important as cosmetics, pigments and potentially biodegradable agrochemicals [8].…”

Ag/Tio2 Nano Thin Films Catalyzed Efficient Synthesis of 6-Amino-4-Aryl-3-Methyl-1,4-Dihydropyrano[2,3-C] Pyrazole-5-Carbonitriles At Green Conditions

“…They exhibited many biological activities like antimicrobial 26 , insecticidal 27 , and anti-inflammatory 28 . Moreover, dihydropyrano [2,3-c]pyrazoles exhibit molluscicidal activity 29 , and has been identified as a screening kit for Chk1 kinase inhibitor 30 . Because of the importance of these compounds, a number of methods have been reported for their synthesis in the presence of various catalysts such as ionic liquids 31,32 , organic bases [33][34][35][36] , amberlyst 37 , glycine 38 , per-6-amino-b-cyclodextrin 39 , and iodine 40 .…”

A Rapid, Convient and Diversified-Multicomponent Synthesis and Characterization of Pyrano[2,3-<i>b</i>]Indoles

“…Compounds containing this moiety have many pharmacological properties and play important roles in biochemical processes. They are reported to possess a multiplicity of pharmacological properties including anticancer 7 , antimicrobial 8 , anti-inflammatory 9 , insecticidal, and molluscicidal activities 10,11 . They are also potential inhibitors of human Chk1 kinase 12 .…”