Synthesis and Microbiological Evaluation of 1-(4-Methyl-6-Nitro-2h-Benzo[b] [1,4]thiazine-3(4h)-Ylidene)hydrazine-1,1-Dioxide Derivatives

Abstract

Objective: The objective of this work was to synthesize and evaluate antimicrobial properties of 1-(4-methyl-6-nitro-2H-benzo [b][1,4]thiazine-3(4H)-ylidene)hydrazine-1,1-dioxide derivatives. Methods:These new compounds were synthesized by methylation in 4-N and reacted with hydrazine derivatives and oxidized at the sulfur atom by 30% hydrogen peroxide to obtain sulfones. All the synthesized compounds were evaluated for antimicrobial activity using the disc diffusion method. Conclusion:Result obtained in this research work clearly indicated that the compound 6f having methyl at 2 position and nitro groups at 2′ and 4′ position showed the most potent antimicrobial activity.

Polyethylene Glycol (PEG‐200): An Efficient, Green and Biocompatible Reaction Medium for the Metal‐Free Synthesis of Functionalized 1,4‐Benzothiazines.

“…Functionalized 1,4-benzothiazines, holding benzene amalgamated with a six-membered thiazine ring, acts for principal group of heterocyclic compounds, which display a wide variety of biological effects. For example, methyl-3-ethyl-6,8-dimethyl-4Hbenzo[b] [1,4]-thiazine-2-carboxylate has been used as antioxidasnt, [4] antimicrobial, [4,5] antifungal, [4] 15-lypoxygenase inhibitor, [4] neuroleptics, [4] antirheumatic, [4] anticancer, [6] calcium antagonist, [4] cardiovascular, [4] antimalarial, [4] anthelmintic [4] agent. 1, 4-benzothiazine derivatives have reported to possess wide applications in medicinal chemistry, [7][8][9] for example it is used for the treatment of low blood sugar or as anti HIV agent [10] etc.…”