Synthesis and <i>In Vitro</i> Antibacterial and Antifungal Evaluation of Quinoline Analogue Azetidin and Thiazolidin Derivatives

Abstract

A library of quinoline analog two novel series of azetidin (SH 1-5 ) and thiazolidin (SH a-e ) derivatives were designed and synthesized with simple and eco-friendly methodologies. The structures of the compounds were elucidated with the aid of elemental analysis, IR, 1 H-NMR and mass spectral data. These novel synthesized compounds were evaluated for antibacterial activity against two grampositive bacteria (Staphylococcus aureus, Staphylococcus pyogenus) and two gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli). The title compounds were also studied for their antifungal activity with Candida albicans, Aspergillus niger, Aspergillus clavatus using the broth dilution technique. Most of the compounds were the best bio-active desired antibacterial analog with less MIC value against different tested strains.

Synthesis, In Vitro Biological Screening, and In Silico Computational Studies of Some Novel Imidazole‐2‐thiol Derivatives

“…In vitro antimicrobial activity of all synthesized novel substituted 2‐((5‐acetyl‐4‐methyl‐1‐phenyl‐1 H ‐imidazole‐2‐yl)thio)‐ N ‐phenylacetamide derivatives were checked against Staphylococcus aureus , Escherichia coli , Streptococcus pyogenes, Pseudomonas aeruginosa strains of antibacterial and Candida albicans , Aspergillus niger , Aspergillus clavatus strains of antifungal by using a method as described by S. M. Prajapati . In vitro antituberculosis activity of all the synthesized derivatives against mycobacterium tuberculosis H37Rv strain was tested by utilizing Lowenstein–Jensen medium (conventional method) as described by A. Rattan .…”

Microwave Induced Facile One-Pot Access to Diverse 2-Cyanobenzothiazole-A Key Intermediate for the Synthesis of Firefly Luciferin

“…Over the last few years, microwave irradiation (MWI) has emerged a great energy source for the wide range of organic transformation with short reaction time and high yield of the products with high purity [6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Hence, a study has been undertaken using microwave irradiation for the condensation of ortho-aminothiophenol with ethyl cyanoformate using Lawesson's reagent under solvent and catalyst free condition (Scheme 4).…”