Synthesis and laser activity of halo‐acridinedione derivatives

Kaya, Muharrem; Yıldırır, Yılmaz; Türker, Lemi

doi:10.1002/jhet.45

Cited by 27 publications

(14 citation statements)

References 19 publications

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“…The solvent of the organic phase was evaporated in a rotary evaporator. 1,8-Dioxoacridine 4l was separated from the residue by TLC, dried, and then recrystallized from CHCl 3 -MeOH (9 : 1) [14]. Synthesis, Characterization, and In Vitro Antimicrobial and Antifungal Activity 725 ramethyl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H) …”

Section: Synthesismentioning

confidence: 99%

Synthesis, Characterization, and In Vitro Antimicrobial and Antifungal Activity of Novel Acridines

2015

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Novel acridines (4a -4l) were synthesized by reaction of tetraketones (3a, 3b) and aromatic amines. The structures of compounds were characterized by FT-IR, 1 H NMR, mass spectroscopy, and elemental analysis. Furthermore, all the synthesized compounds were tested in vitro for their antimicrobial and antifungal activity. The results were compared with conventional reference antibiotics. Many of the acridine compounds considerably reacted against Esherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis, and Staphylococcus aureus. Particularly, compound 4k showed more pronounced activity than reference antibiotics against Salmonella enteritidis. All the compounds showed moderate activities against Candida albicans and Candida glabrata.

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Section: Synthesismentioning

confidence: 99%

Synthesis, Characterization, and In Vitro Antimicrobial and Antifungal Activity of Novel Acridines

2015

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“…The infrared (IR) spectra of all the acridine carboxylic acid derivatives showed sharp peaks for the carbonyl groups in the region between 1624 and 1725 cm -l (Kaya et al, 2009). The compounds 5 and 9 that belong to CN group exhibited peaks at 2224 and 2228 cm -1 , respectively (Kaya et al, 2011).…”

Section: Chemistrymentioning

confidence: 99%

Rapid synthesis of novel 1,8-dioxoacridine carboxylic acid derivatives by microwave irradiation and their free radical scavenging activity

et al. 2015

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Synthesis of novel acridine carboxylic acid compounds 4-18 was performed with the reaction of 4-aminobenzoic acid 1, aromatic aldehyde 2a-n, 1,3-diketone 3a, 3b using microwave irradiation. These compounds were synthesized efficiently in one-pot procedure for 6 min without catalyst in high yields of 65-90 % using little ethanol. Radical scavenging activities of synthesized compounds 4-18 were determined by means of in vitro test using 2,2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid radicals (ABTS Á? ). The activities of tested compounds were compared to the positive control such as butylated hydroxyanisole, butylated hydroxytoluene, and trolox. The results showed that the synthesized compounds 4, 6, 14, and 15 had effective free radical scavenging activity.

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“…Analytical TLC and column chromatography were performed on silica gel GF254 and silica gel H60, respectively. : 3,3,6,4,6,7,9,…”

Section: Generalmentioning

confidence: 99%

“…Acridines which possess the 1,4-dihydropyridine parent nucleus have interesting pharmaceutical properties such as a positive iontropic effects promoting the entry of calcium to the intracellular space [2], and 1,8-(2H,5H)-acridinediones are known as laser dyes [3].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of N-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water

Xia

Zhang

2012

Molecules

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Acridinediones were synthesized by the one-pot Hantzsch condensation of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, and aniline/4-methylaniline in refluxing water. This method has then been extended to the four-component reaction of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, ethyl acetoacetate and ammonium acetate for the synthesis of polyhydroquinoline derivatives. This is an environmentally friendly and efficient procedure providing good to excellent yields.

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Synthesis and laser activity of halo‐acridinedione derivatives

Cited by 27 publications

References 19 publications

Synthesis, Characterization, and In Vitro Antimicrobial and Antifungal Activity of Novel Acridines

Synthesis, Characterization, and In Vitro Antimicrobial and Antifungal Activity of Novel Acridines

Rapid synthesis of novel 1,8-dioxoacridine carboxylic acid derivatives by microwave irradiation and their free radical scavenging activity

Synthesis of N-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water

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