Synthesis and Larvicidal Activity against Culex pipiens pallens of New Triazole Derivatives of Phrymarolin from Phryma leptostachya L.

Abstract

Twelve new triazole derivatives of Phrymarolin were prepared from Phrymarolin I and the structures of all the derivatives were fully characterized by 1H-NMR, 13C-NMR and MS spectral data analyses. Larvicidal activities against 4rd instar larvae of Culex pipiens pallens of these Phrymarolin analogues were assayed. Although the triazole derivatives of Phrymarolin showed certain larvicidal activity, they showed lower activity than Phrymarolin I. The typical non-natural groups triazole substituents reduced the larvicidal activity of Phrymarolin derivatives.

Insecticidal Activity of Four Lignans Isolated from Phryma leptostachya

“…Previous phytochemical investigations showed that this plant is rich in lignans, many of which have a unique oxygenated 3,7-dioxabicyclo[3.3.0]octane skeleton, such as phrymarolin I, II, and haedoxan A [1,10,11,12]. In general, these lignans are considered as the main insecticidal active ingredients in P. leptostachya [13,14].…”

Microwave Assistant Synthesis, Antifungal Activity and DFT Theoretical Study of Some Novel 1,2,4-Triazole Derivatives Containing Pyridine Moiety

“…1,2,4-Triazole rings are typically planar aromatic systems, featuring an extensive chemistry [ 10 , 11 ]. 1,2,4-Triazole derivatives represent one of the most biologically active classes of heterocyclic compounds, and their derivatives are characterized with a broad spectrum of biological activity, including anti-cancer activity [ 12 ], antiparasitic activity [ 13 ], larvicidal activity[ 14 ], antifungal activity [ 15 ], herbicidal activity [ 16 , 17 ], antioxidant activity [ 18 ], cytostatic activity [ 19 ], brassinosteroid biosynthesis inhibitors [ 20 ], antimicrobial activity [ 21 ], and so on. Some compounds had been developed as commercial fungicides or herbicides ( Figure 1 ), such as Triadimefon, Triadimenol, Flusilazole, Flupoxamand, and so on.…”

Synthesis and Larvicidal Activity of Phrymarolin Derivatives against Culex Pipiens Pallens

“…The herbaceous perennial plant, Phryma leptostachya L., is widely distributed in the Himalayas, temperate Asia and northeast America, and has been traditionally used as a natural insecticide in East Asia [2][3][4][5][6][7]. As part of an ongoing effort to identify potential pesticide molecules derived from natural products it was shown that lignans are the main active components of P. leptostachya, and phrymarolin I is a representative member of the lignans isolated from this plant [5][6][7][8]. In this paper, the synthesis and larvicidal activity of novel derivatives of phrymarolin I against Culex pipiens pallens are described.…”