Synthesis and investigation of tuberculosis inhibition activities of some 1,2,3-triazole derivatives

Click Chemistry: 1,2,3‐Triazoles as Pharmacophores

“…Dabak and co-workers studied antitubercular activity of 4-acyl-1 H-1,2,3-triazole derivatives, which were synthesized by condensation of a-diazo-b-oxoaldehyde compounds with different amines. [98] 5-Azido-5-deoxyxylo-, ribo-, and arabinofuranoses (33) were found to show antitubercular activity against Mycobacterium tuberculosis H37Rv. [99] The best compound displayed antitubercular activity with MIC 12.5 mg mL À1 .…”

“…[164] Gigure et al described the synthesis of stable galactosides and lactosides as potential Gal-1 and Gal-3 inhibitors against galectins, which compared well with known inhibitors. [165] The best dimers were bis-lactosides (98), which have both inhibitory properties of 160 mm.…”

Fighting tuberculosis: An old disease with new challenges

“…17). In addition to the above, other classes of molecules that have been evaluated for their antitubercular activities comprise 4-(coumarinyl)-4-thiozolin-2-one-benzylidene-hydrazones, 247 3-hydrazono-1 H-2-indolinones, 248 quinoxaline-1, 4-di-N-oxides, 249 cyclohexadiene 250 N-(2-naphthyl) glycin hydrazide analogous, 251 isoxazoles and cynopyridines, 252 4-phenyl-1, 8-naphthyridine, 253 aminolupinanes, 254 benzoyl thiozole-2-carbamates, 255 thiosemicarbazones, 256 dithiocarbamates, 257 thiazolidinones, [258][259][260] succinamides, 261 diarylsuccinamides, 262 glutaconyl-thiosemicarbazides, 263 2,2 0 -dithio-bis (benzamides), 264 1,3,5-triazines, 265 trimethyl silyl-3-(carbethoxy carbamoyl) propionates 266 pyrrolnitrin and pyrrole derivatives [267][268][269][270] diguanidino and ''reversed'' diamidino 2,5-diaryl-furans, 271 1,2,4 triazoles, 272,273 thiazole, 274 1,3,5 thiadiazole, 275 quinazolines, 276 quinolines, 277 3-Me-N 0 (disubstituted-quinolinyl) pyrazol-5-ones 278 quinoxaline 1,4 dioxides, 279 quinoxaline-2-carboxamide 1,4-di-N-oxide, 280 nitroquinolones, 281 2,4-dihydroxy quinolines 282 3nitro-and 3-bromo-4-hydroxy-2 quinooines, 283 quinazolinones, 284 6-nitro quinazolones, 285 benzimidazole, 286 benzazole 287 substituted 2-(4-amino phenyl sulphonamido)-benzothiazoles, 288 3-aryl substit...…”

Synthesis and Anticonvulsant Activity of 1-Substituted-7-Benzyloxy-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline

“…The derivatives of triazole exhibit a variety of activities such as antitumor, 4) antiinflammatory, 5) antimicrobial, 6,7) antifugal, 8) antithrombotic, 9) antiplatelet, 10) antiviral, 11) and anticonvulsant activities. [12][13][14] In our search for new compounds with anticonvulsant activity, 6-benzyloxy-3,4-dihydro-1H-quinoline-2-one was found although its activity is low.…”