Synthesis and Investigation of Tuberculosis Inhibition Activities of Some 1,2,3‐Triazole Derivatives.

Abstract

Triazole derivativesTriazole derivatives R 0280 Synthesis and Investigation of Tuberculosis Inhibition Activities of Some 1,2,3-Triazole Derivatives. -Condensation of α-diazo-β-oxoaldehydes (I) with different amines (II) affords the title compounds in good yields. -(DABAK*, K.; SEZER, O.; AKAR, A.; ANAC, O.; Eur. J. Med. Chem. 38 (2003) 2, 215-218; Dep. Chem., Fac. Sci., Tech. Univ. Istanbul, TR-80626 Maslak, Istanbul, Turk.; Eng.) -M. Paetzel 24-107

Synthesis, characterization and biological properties of thienyl derived triazole Schiff bases and their oxovanadium(IV) complexes

“…Compounds having S, N and O donor atoms play a vital role in antibacterial [1][2][3] , antifungal 4,5 , antitumor 6 , antitubercular 7,8 , anticancer 9 and antiviral 10 activities due to their significant biological properties. Presently, the vanadium metal chemistry is gaining attention for its remarkable activities such as antimicrobial 11 , antitumor 12 , and most recently as insulin mimetic 13 .…”

Some biologically active oxovanadium(IV) complexes of triazole derived Schiff bases: their synthesis, characterization and biological properties

“…They coordinate to the metal ion in many ways, depending upon the nature of the functional groups [8][9][10][11] . Studies have indicated that many triazole derived Schiff bases show antibacterial [12][13][14] , antifungal 15,16 , antimicrobial [17][18][19][20] , anticancer 21,22 , analgesic 23 , anticonvulsant 24 , antitumor [25][26][27] , antitubercular [28][29][30][31] , insecticidal, herbicidal, and plant growth regulatory [32][33][34] activities. Due to increased interest in the chemistry of vanadyl compounds and the potentially bioactive nature of triazoles, we have made an effort to combine the chemistry of vanadium(IV) with newly synthesized triazole Schiff bases L 1 -L 5 (Scheme 1).…”

Crystal structure of ethyl 1-(4-chlorophenyl)-5-methyl-1H-1,2,3-triazole-4 carboxylate, C12H12ClN3O2

“…1,2,3-Triazoles are an important class of heterocyclic compounds due to their wide range of applications as pharmaceutical agents [5,6]. The diversity of chemical structures of the 1,2,3-triazole family and their useful biological activities made these compounds attractive targets in synthetic organic chemistry and many studies have been reported on the synthesis of these compounds [7][8][9].…”